Leukocytes--second line of defense against invading mastitis pathogens.

In mammals, neutrophile polymorphonuclear leukocytes constitute one of the essential body defenses against disease. In a large mammal, such as the dairy cow, billions of neutrophils are mobilized to fight infection. For example, over 50 million neutrophils per milliliter milk are commonly in a mammary quarter inflicted with clinical mastitis. However, in spite of these numerous leukocytes, pathogenic organisms remain viable. Recent evidence indicates that bacteria are not eliminated from a diseased quarter because the phagocytic capacity of the neutrophils is reduced in the mammary gland. The morphology and physiology of the leukocyte is examined in this review in an attempt to explain why the phagocytic capacity of the neutrophil is reduced in the mammary gland of the bovine.