通过硅氢化反应实现非天然β-硅基-α-氨基酸的光氧化还原无金属合成。
Photoredox Metal-Free Synthesis of Unnatural β-Silyl-α-Amino Acids via Hydrosilylation.
作者信息
Wang Guo-Qin, Wang Ting, Zhang Yue, Zhou Yuan-Xia, Yang Dan, Han Pan, Jing Lin-Hai
机构信息
Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, 637002, P.R. China.
出版信息
Chem Asian J. 2023 Dec 14;18(24):e202300805. doi: 10.1002/asia.202300805. Epub 2023 Nov 9.
An efficient, practical and metal-free methodology for the synthesis of β-silyl-α-amino acid motifs via photoredox and hydrogen atom transfer (HAT) process is described. This protocol enables the direct hydrosilylation of dehydroalanine derivatives and tolerates a wide array of functional groups and synthetic handles, leading to valuable β-silyl-α-amino acids with moderate to good yields.
本文描述了一种通过光氧化还原和氢原子转移（HAT）过程合成β-硅基-α-氨基酸基序的高效、实用且无金属的方法。该方案能够实现脱氢丙氨酸衍生物的直接硅氢化反应，并能耐受多种官能团和合成基团，从而以中等到良好的产率得到有价值的β-硅基-α-氨基酸。
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