Albus M, Stahl S, Müller-Spahn F, Engel R R
Biol Psychol. 1986 Aug;23(1):39-51. doi: 10.1016/0301-0511(86)90088-8.
To evaluate the influence of beta-blockers and/or minor tranquillizers on autonomic reactions during brief stress, 48 healthy subjects were randomised into 4 groups: A = 4 mg Pindolol, B = 1.5 mg Cloxazolam, C = Placebo, D = 4 mg Pindolol + 1.5 mg Cloxazolam. Subjects underwent four stress situations: Counting, noise, mental arithmetic and ergometry, each lasting 4 min with rest periods of 8 min in between. Electromyogram, finger pulse amplitude, heart rate, pulse wave velocity and electrodermal activity were recorded simultaneously on-line. Analysis of variance showed that the two drugs had significant main effects in different systems: Pindolol reduced heart rate, mainly during mental arithmetic and ergometry, Cloxazolam reduced electrodermal activity, mainly during noise. It can be concluded that different structured situations with a varying amount and type of anxiety induce different autonomic reactions; these reactions can be differentially modified by the drugs applied.
为评估β受体阻滞剂和/或小剂量镇静剂对短暂应激期间自主神经反应的影响，将48名健康受试者随机分为4组：A组 = 4 mg吲哚洛尔，B组 = 1.5 mg氯恶唑仑，C组 = 安慰剂，D组 = 4 mg吲哚洛尔 + 1.5 mg氯恶唑仑。受试者经历四种应激情况：计数、噪音、心算和测力计测试，每种情况持续4分钟，中间有8分钟的休息时间。同时在线记录肌电图、手指脉搏振幅、心率、脉搏波速度和皮肤电活动。方差分析表明，这两种药物在不同系统中具有显著的主要作用：吲哚洛尔降低心率，主要在心算和测力计测试期间；氯恶唑仑降低皮肤电活动，主要在噪音期间。可以得出结论，不同结构的情况，焦虑的程度和类型不同，会引发不同的自主神经反应；这些反应可被所用药物有差异地改变。
