Braune S, Albus M, Fröhler M, Höhn T, Scheibe G
Department of Neurology, Hospital of the University of Freiburg, Germany.
Eur Arch Psychiatry Clin Neurosci. 1994;244(2):86-92. doi: 10.1007/BF02193524.
A group of 27 patients with panic disorder with or without agoraphobia were compared with 10 control subjects before stress exposure. No statistically significant differences between patients and controls were found for the cardiovascular parameters. Skin conductance level and skin conductance reaction were significantly higher in the patient group. They also showed higher self-ratings in behavioural symptoms associated with anxiety. There were statistically significant higher venous plasma levels of norepinephrine in patients than in controls, although the epinephrine levels were similar. The number of binding sites of alpha 2-receptors and the affinity of 3H-yohimbine to the alpha 2-receptors on intact thrombocytes was statistically significantly lower in patients compared to controls. Significant differences between the gender groups of patients and controls were found for electrodermal activity and epinephrine levels. These data add further evidence to an overshooting activation of the noradrenergic pathway in patients with panic disorder, possibly based on a dysregulation of alpha 2-receptor.
在压力暴露前，将27名伴有或不伴有广场恐惧症的惊恐障碍患者与10名对照受试者进行了比较。患者和对照在心血管参数方面未发现统计学上的显著差异。患者组的皮肤电导率水平和皮肤电导率反应显著更高。他们在与焦虑相关的行为症状方面也有更高的自我评分。患者的静脉血浆去甲肾上腺素水平在统计学上显著高于对照，尽管肾上腺素水平相似。与对照相比，患者完整血小板上α2受体的结合位点数量以及3H-育亨宾对α2受体的亲和力在统计学上显著更低。在患者和对照的性别组之间，发现皮肤电活动和肾上腺素水平存在显著差异。这些数据进一步证明了惊恐障碍患者去甲肾上腺素能通路的过度激活，这可能基于α2受体的调节异常。
