Pageaux J F, Laugier C, Pal D, D'Almeida M A, Sandoz D, Pacheco H
Biol Reprod. 1986 Oct;35(3):657-66. doi: 10.1095/biolreprod35.3.657.
The histological development of the quail oviduct and the changes in concentrations of progesterone receptor, ovalbumin, conalbumin, ovomucoid and ovoglycocomponents are analyzed during the period spanning 7-35 days of age. The initiation of luminal epithelial cell proliferation is the first event of magnum growth. The epithelial cells begin to evaginate into subepithelial stroma and form tubular glands. Meanwhile, luminal epithelium starts cellular pleomorphism through ciliogenesis. No egg white proteins are detectable in the developing glands; at the same time, the concentration of the progesterone receptor increases from about 5500 sites/cell to 30,300 sites/cell. Tubular gland cells then begin to synthetize and accumulate egg white proteins, mucous cells differentiate in the luminal epithelium, and the cell proliferation decreases and finally stops. Compared with earlier studies dealing with the blood levels of estrogen and progesterone in developing quails during the same period, and the cellular changes induced in the oviducts of ovariectomized and ovariectomized-hypophysectomized quail by exogenous steroids, these results distinguish between the cellular responses that are physiologically controlled by estradiol and other responses that have multihormonal regulation.
分析了7至35日龄鹌鹑输卵管的组织学发育以及孕酮受体、卵清蛋白、伴清蛋白、卵类黏蛋白和卵糖成分浓度的变化。管腔上皮细胞增殖的启动是输卵管膨大部生长的首个事件。上皮细胞开始向皮下基质内陷并形成管状腺。与此同时，管腔上皮通过纤毛发生开始出现细胞多形性。在发育中的腺体中检测不到蛋清蛋白；与此同时，孕酮受体浓度从约5500位点/细胞增加到30300位点/细胞。然后，管状腺细胞开始合成并积累蛋清蛋白，黏液细胞在管腔上皮中分化，细胞增殖减少并最终停止。与同期关于发育中鹌鹑血液中雌激素和孕酮水平的早期研究，以及外源性类固醇对去卵巢和去卵巢-垂体切除鹌鹑输卵管诱导的细胞变化相比，这些结果区分了由雌二醇生理控制的细胞反应和具有多激素调节的其他反应。
