Camhi Dana, López María Ignacia, Wiener Alan, Heinriksen Karin, Pérez Ignacio, Verdugo Fernando, Rosas Reinaldo, Farías Pamela
Facultad de Medicina, Universidad de los Andes, Santiago, Chile.
Hospital Militar de Santiago, Santiago, Chile.
Rev Med Chil. 2023 Feb;151(1):125-128. doi: 10.4067/s0034-98872023000100125.
COVID-19 disease is associated with a significant number of opportunistic infections, including invasive fungal infections such as mucormycosis. The prevalence of the latter is rare, estimated to be between 0.005 and 1.7 per million inhabitants. Risk factors include hematological diseases, Diabetes Mellitus with poor metabolic control, solid organ transplantation, neutropenia, and prolonged administration of systemic corticosteroids. We report two males aged 60 and 75 years with pulmonary and tracheobronchial invasive mucormycosis, respectively. Both patients had a deficient metabolic control of their diabetes as a predisposing risk factor added to severe COVID-19 infection. High suspicion and early diagnosis are essential for prompt treatment, especially considering the associated high morbidity and mortality of this fungal infection.
新冠肺炎与大量机会性感染有关,包括毛霉菌病等侵袭性真菌感染。后者的患病率很低,估计每百万居民中为0.005至1.7例。危险因素包括血液系统疾病、代谢控制不佳的糖尿病、实体器官移植、中性粒细胞减少症以及长期使用全身性皮质类固醇。我们报告了两名分别为60岁和75岁的男性,他们分别患有肺部和气管支气管侵袭性毛霉菌病。两名患者均存在糖尿病代谢控制不佳的情况,这是加重严重新冠肺炎感染的一个易感危险因素。高度怀疑和早期诊断对于及时治疗至关重要,尤其是考虑到这种真菌感染相关的高发病率和死亡率。