Department of Abdominal Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.
Life Sci. 2023 Dec 1;334:122215. doi: 10.1016/j.lfs.2023.122215. Epub 2023 Oct 29.
Sonodynamic therapy (SDT) is a new non-invasive treatment method proposed based on photodynamic therapy (PDT). It has advantages such as high precision, strong tissue penetration, minimal side effects, and good patient compliance. With the maturation of nanomedicine, the application of nanosonosensitizers has further propelled the development of SDT. In recent years, people have developed many new types of sonosensitizers and explored the mechanisms of SDT. Among them, the studies about the relationship between autophagy and SDT have attracted increasing attention. After the SDT, cells usually undergo autophagy as a self-protective mechanism to resist external stimuli and reduce cell damage, which is beneficial for the treatment of atherosclerosis (AS), diabetes, and myocardial infarction but counterproductive in cancer treatment. However, under certain treatment conditions, excessive upregulation of autophagy can also promote cell death, which is beneficial for cancer treatment. This article reviews the latest research progress on the relationship between SDT and autophagy in cancers, AS, diabetes, and myocardial infarction. We also discuss and propose the challenges and prospects in enhancing SDT efficacy by regulating autophagy, with the hope of promoting the development of this promising therapeutic approach.
声动力学疗法（SDT）是基于光动力学疗法（PDT）提出的一种新的非侵入性治疗方法。它具有精度高、组织穿透性强、副作用小、患者顺应性好等优点。随着纳米医学的成熟，纳米声敏剂的应用进一步推动了 SDT 的发展。近年来，人们开发了许多新型声敏剂，并探索了 SDT 的机制。其中，自噬与 SDT 之间关系的研究引起了越来越多的关注。SDT 后，细胞通常会通过自噬作为一种自我保护机制来抵抗外部刺激，减少细胞损伤，这有利于动脉粥样硬化（AS）、糖尿病和心肌梗死的治疗，但在癌症治疗中却适得其反。然而，在某些治疗条件下，过度上调自噬也可以促进细胞死亡，有利于癌症治疗。本文综述了 SDT 与癌症、AS、糖尿病和心肌梗死中自噬关系的最新研究进展。我们还讨论并提出了通过调节自噬增强 SDT 疗效所面临的挑战和前景，以期促进这一有前途的治疗方法的发展。
