Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
Int J Mol Sci. 2023 Jul 26;24(15):12001. doi: 10.3390/ijms241512001.
Sonodynamic therapy (SDT) is an emerging non-invasive cancer treatment method in the field of nanomedicine, which has the advantages of deep penetration, good therapeutic efficacy, and minimal damage to normal tissues. Sonosensitizers play a crucial role in the process of SDT, as their structure and properties directly determine the treatment outcome. Inorganic sonosensitizers, with their high stability and longer circulation time in the human body, have great potential in SDT. In this review, the possible mechanisms of SDT including the ultrasonic cavitation, reactive oxygen species generation, and activation of immunity are briefly discussed. Then, the latest research progress on inorganic sonosensitizers is systematically summarized. Subsequently, strategies for optimizing treatment efficacy are introduced, including combination therapy and image-guided therapy. The challenges and future prospects of sonodynamic therapy are discussed. It is hoped that this review will provide some guidance for the screening of inorganic sonosensitizers.
声动力学疗法（SDT）是纳米医学领域中一种新兴的非侵入性癌症治疗方法，具有穿透力深、疗效好、对正常组织损伤小等优点。声敏剂在 SDT 过程中起着至关重要的作用，因为它们的结构和性质直接决定了治疗效果。无机声敏剂具有较高的稳定性和更长的在人体内循环时间，在 SDT 中有很大的应用潜力。在这篇综述中，简要讨论了 SDT 的可能机制，包括超声空化、活性氧的产生和免疫的激活。然后，系统总结了无机声敏剂的最新研究进展。随后，介绍了优化治疗效果的策略，包括联合治疗和图像引导治疗。讨论了声动力学疗法的挑战和未来前景。希望这篇综述能为无机声敏剂的筛选提供一些指导。
