Tavassoli M
Blood Cells. 1986;12(1):205-16.
The presence of marrow cells within the cytoplasm of megakaryocytes has been documented and is attributed to the phenomenon of emperipolesis. In a previous study most patients demonstrating this phenomenon had or were suspected of having blood loss. To find out if these are causally related, we induced acute and chronic blood loss in rats and quantitatively measured the emperipolesis index (EI). EI dropped after acute blood loss but rose after chronic blood letting, indicating that blood loss can modulate this phenomenon. In the marrow, megakaryocytes are located preferentially on the abluminal side of sinus endothelium and it is postulated that in the state of heightened demand for cell delivery from marrow into the circulation, some cells take a transmegakaryocytic route to enter the circulation. This concept incorporates megakaryocytes as a component of the marrow-blood barrier.
巨核细胞胞质内存在骨髓细胞已被记录在案，这归因于细胞入胞现象。在先前的一项研究中，大多数表现出这种现象的患者有或疑似有失血情况。为了弄清楚这些是否存在因果关系，我们在大鼠中诱导急性和慢性失血，并定量测量细胞入胞指数（EI）。急性失血后EI下降，但慢性放血后EI上升，表明失血可调节这种现象。在骨髓中，巨核细胞优先位于窦内皮的腔外侧，据推测，在骨髓向循环系统输送细胞的需求增加的状态下，一些细胞会通过巨核细胞途径进入循环系统。这一概念将巨核细胞纳入骨髓 - 血液屏障的组成部分。
