多发性硬化症免疫遗传特征与 12 种病毒的计算机免疫原性之间的负相关关系。

Negative association between multiple sclerosis immunogenetic profile and in silico immunogenicities of 12 viruses.

机构信息

The HLA Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, MN, 55417, USA.

Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.

出版信息

Sci Rep. 2023 Oct 31;13(1):18654. doi: 10.1038/s41598-023-45931-5.

DOI:10.1038/s41598-023-45931-5

PMID:37907711

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10618254/

Abstract

Human Leukocyte Antigen (HLA) is involved in both multiple sclerosis (MS) and immune response to viruses. Here we investigated the virus-HLA immunogenicity (V-HLA) of 12 viruses implicated in MS with respect to 17 HLA Class I alleles positively associated to MS prevalence in 14 European countries. Overall, higher V-HLA immunogenicity was associated with smaller MS-HLA effect, with human herpes virus 3 (HHV3), JC human polyoma virus (JCV), HHV1, HHV4, HHV7, HHV5 showing the strongest association, followed by HHV8, HHV6A, and HHV6B (moderate association), and human endogenous retrovirus (HERV-W), HHV2, and human papilloma virus (HPV) (weakest association). These findings suggest that viruses with proteins of high HLA immunogenicity are eliminated more effectively and, consequently, less likely to be involved in MS.

摘要

人类白细胞抗原（HLA）参与多发性硬化症（MS）和对病毒的免疫反应。在这里，我们研究了 12 种与 MS 相关的病毒的病毒-HLA 免疫原性（V-HLA），涉及到与 14 个欧洲国家 MS 流行率相关的 17 个 HLA Ⅰ类等位基因。总体而言，较高的 V-HLA 免疫原性与较小的 MS-HLA 效应相关，人类疱疹病毒 3（HHV3）、JC 人多瘤病毒（JCV）、HHV1、HHV4、HHV7、HHV5 关联最强，其次是 HHV8、HHV6A 和 HHV6B（中度关联），以及人类内源性逆转录病毒（HERV-W）、HHV2 和人乳头瘤病毒（HPV）（关联最弱）。这些发现表明，具有高 HLA 免疫原性的蛋白质的病毒被更有效地清除，因此不太可能参与 MS。