Infection Bioengineering Group, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, India.
Cellular and Molecular Neurobiology Unit, Indian Institute of Technology, Jodhpur, India.
J Neuroimmunol. 2021 Sep 15;358:577636. doi: 10.1016/j.jneuroim.2021.577636. Epub 2021 Jun 19.
Herpesviruses like Epstein-Barr virus, human herpesvirus (HHV)-6, HHV-1, VZV, and human endogenous retroviruses, have an age-old clinical association with multiple sclerosis (MS). MS is an autoimmune disease of the nervous system wherein the myelin sheath deteriorates. The most popular mode of virus mediated immune system manipulation is molecular mimicry. Numerous herpesvirus antigens are similar to myelin proteins. Other mechanisms described here include the activity of cytokines and autoantibodies produced by the autoreactive T and B cells, respectively, viral déjà vu, epitope spreading, CD46 receptor engagement, impaired remyelination etc. Overall, this review addresses the host-parasite association of viruses with MS.
疱疹病毒，如 Epstein-Barr 病毒、人类疱疹病毒（HHV）-6、HHV-1、水痘带状疱疹病毒和人类内源性逆转录病毒，与多发性硬化症（MS）有着悠久的临床关联。MS 是一种自身免疫性神经系统疾病，其中髓鞘会恶化。病毒介导的免疫系统操纵的最流行模式是分子模拟。许多疱疹病毒抗原与髓鞘蛋白相似。这里描述的其他机制包括由自身反应性 T 和 B 细胞分别产生的细胞因子和自身抗体的活性、病毒先占、表位扩展、CD46 受体结合、髓鞘再生受损等。总的来说，本综述探讨了病毒与 MS 的宿主-寄生虫关联。
