Al-Karak University College, Al-Balqa Applied University, Department of Medical Support, Al-Karak, Jordan.
Mu'tah University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Al-Karak, Jordan.
Braz J Biol. 2023 Oct 30;83:e275382. doi: 10.1590/1519-6984.275382. eCollection 2023.
Significant risk factors for atherosclerosis include hyperlipidemia and oxidative stress, which together rank as three of the most significant risk factors for cardiovascular diseases. Securigera securidaca lowers cholesterol levels in diabetic rats' blood. This investigation's objective was to determine how methanolic extracts affected the flowers, leaves, and seeds of plants in rats that were fed a high-fat diet (HFD). Five groups of animals were created (n = 5). A total of 35 days, divided into two intervals, were used for the study. Rats received HFD during the first 15-day interval, while during the second 20-day interval, they also received extracts or the Atorvastatin reference drug. The extract of seeds has a high phenol content as well as DPPH radical antioxidant activity. Extracts were given at a dose of 200 mg/kg; p.o. Methanolic treatment of S. securidaca flowers, leaves, and seeds in HFD-induced hyperlipidemic rats resulted in significant reductions in total cholesterol, triglycerides, LDLC, and VLDL-C levels. HDL-C levels increased significantly because of the leaves. While in hyperlipidemic rats, seeds significantly reduced the activities of the enzymes ALT and ALP. The findings showed that, to a certain extent, seeds, flowers, and leaves may have benefits in reducing hyperlipidemia brought on by HFD in terms of lipid profiles and liver function enzymes. The findings of this study indicate a promising application prospect, but more research is needed to determine the exact mechanism of these novel compounds as antihyperlipidemic agents and to clarify their potential combination effect with synthetic drugs such as Atorvastatin. Combinations can reduce the dose of chemical medications required, which lowers the risk of side effects.
动脉粥样硬化的显著危险因素包括高血脂和氧化应激，这两者共同构成了心血管疾病的三大最重要危险因素之一。地构叶可降低糖尿病大鼠血液中的胆固醇水平。本研究的目的是确定高脂肪饮食（HFD）喂养的大鼠中，植物花、叶和种子的甲醇提取物如何发挥作用。共创建了 5 组动物（n = 5）。研究共进行了 35 天，分为两个间隔。第一 15 天间隔期间，大鼠接受 HFD，而在第二 20 天间隔期间，它们还接受提取物或阿托伐他汀参比药物。种子提取物具有高酚含量和 DPPH 自由基抗氧化活性。提取物的剂量为 200mg/kg；p.o. 地构叶花、叶和种子的甲醇提取物处理 HFD 诱导的高脂血症大鼠，可显著降低总胆固醇、甘油三酯、LDLC 和 VLDL-C 水平。HDL-C 水平因叶片而显著升高。在高脂血症大鼠中，种子显著降低了 ALT 和 ALP 酶的活性。研究结果表明，在一定程度上，种子、花和叶可能对降低 HFD 引起的高脂血症具有益处，这体现在脂质谱和肝功能酶方面。本研究的结果表明了一个有前途的应用前景，但需要进一步的研究来确定这些新型化合物作为抗高血脂药物的确切作用机制，并阐明它们与阿托伐他汀等合成药物的潜在组合效应。组合可以减少所需的化学药物剂量，从而降低副作用的风险。
