Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, P. O. Box 80203, Jeddah-21589, Saudi Arabia; Stem Cell P2 Laboratory, The Center for Reproductive Medicine, Shantou University Medical College, Shantou, 515041, People's Republic of China.
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, P. O. Box 80203, Jeddah-21589, Saudi Arabia.
Biomed Pharmacother. 2018 Nov;107:675-680. doi: 10.1016/j.biopha.2018.07.134. Epub 2018 Aug 17.
In the present study, we investigated the hypolipidemic and hepatoprotective potential of the commercially available crushed Ajwa date seed-extract on the toxicity caused by the atorvastatin in high-fat diet (HFD)-induced hyperlipidemic rats. Male albino rats were divided into two main groups, Group I (normal control) and Group II (HFD); Group II was further divided into four subgroups: Group IIa (HFD control), Group IIb (Atorvastatin: A10)-6 rats were administered with 10 mg/kg atorvastatin daily for 30 days, Group IIc (Ajwa seed extract: AJ)-6 rats were given 1000 mg/kg Ajwa seed extract daily for 30 days, Group IId (AJ + A10)-6 rats were given Ajwa seed extract 1000 mg/kg and Atorvastatin 10 mg/kg daily for 30 days. The data obtained suggested that Ajwa seed extract lowered the serum cholesterol level in HFD rats and demonstrated the hepatoprotective effect in combination with atorvastatin by reducing the levels of ALT and AST. In conclusion, it protected the tissues from the detrimental effects of hyperglycemia and enhanced antioxidant activity. Furthermore, the dose-limiting toxicity of atorvastatin may be reduced if the Ajwa seed extract is incorporated in the current treatment regimens to treat hyperlipidemia in hypercholesteremic individuals.
在本研究中，我们研究了市售的 Ajwa 椰枣种子提取物对阿托伐他汀在高脂饮食（HFD）诱导的高血脂大鼠引起的毒性的降血脂和保肝作用。雄性白化大鼠分为两组，第一组（正常对照组）和第二组（HFD）；第二组进一步分为四个亚组：第二组 a（HFD 对照组），第二组 b（阿托伐他汀：A10）-6 只大鼠每天给予 10mg/kg 阿托伐他汀 30 天，第二组 c（Ajwa 种子提取物：AJ）-6 只大鼠每天给予 1000mg/kg Ajwa 种子提取物 30 天，第二组 d（AJ+A10）-6 只大鼠给予 Ajwa 种子提取物 1000mg/kg 和阿托伐他汀 10mg/kg 每天 30 天。所得数据表明，Ajwa 椰枣种子提取物可降低 HFD 大鼠的血清胆固醇水平，并与阿托伐他汀联合使用，通过降低 ALT 和 AST 水平，显示出保肝作用。总之，它保护组织免受高血糖的有害影响，并增强抗氧化活性。此外，如果将 Ajwa 椰枣种子提取物纳入当前治疗方案中，以治疗高胆固醇血症患者的高血脂症，可能会降低阿托伐他汀的剂量限制毒性。
