Department of Pathology, Division of Hematopathology, University of Calgary; and.
Department of Medicine, Division of Dermatology, University of Calgary.
Am J Dermatopathol. 2024 Mar 1;46(3):167-169. doi: 10.1097/DAD.0000000000002579. Epub 2023 Oct 26.
In situ follicular B-cell neoplasm (ISFN) is a variant of follicular lymphoma, presenting as an incidental histologic finding in lymph node biopsy or excisional specimens. ISFN presents with a B-cell population that strongly expresses BCL2 and CD10 within the germinal centers of a lymph node or extranodal site. Genetic analysis shows t(14;18) translocation. Herein, we report a case of ISFN presenting as military and agminated facial papules in a young woman, which resolved spontaneously in the postpartum period. To our knowledge, this is the only report of a cutaneous site of involvement of this rare entity.
原位滤泡性 B 细胞肿瘤（ISFN）是滤泡性淋巴瘤的一种变体，表现为偶然发现的淋巴结活检或切除标本中的组织学表现。ISFN 表现为 B 细胞群体，在淋巴结或结外部位的生发中心内强烈表达 BCL2 和 CD10。基因分析显示 t（14；18）易位。本文报告了一例 ISFN，表现为年轻女性的多发性军事性面部丘疹，在产后期间自发消退。据我们所知，这是该罕见实体累及皮肤部位的唯一报道。
