University of Yamanashi Faculty of Medicine, General thoracic surgery, Shimokato1110, Chuo Yamanashi, Japan.
Department of Pathology, University of Yamanashi Faculty of Medicine, University of Yamanashi, Chuo Yamanashi, Japan.
Thorac Cancer. 2023 May;14(15):1401-1403. doi: 10.1111/1759-7714.14878. Epub 2023 Apr 3.
In situ follicular B cell neoplasm, previously known as follicular lymphoma in situ, is a neoplastic proliferation of follicular lymphoma-like B cells confined to the germinal centers. Herein, we report a case of a woman in her 70s who initially presented with several enlarged abdominal lymph nodes. Seven months later during follow-up, a solitary pulmonary nodule was detected. As it was close to the hilum, lobectomy was performed. The intraoperative frozen section showed fibrosis and a collection of lymphocytes and macrophages. Therefore, the lymph nodes were sampled. Station 4 and 10 lymph nodes exhibited similar tumor cells and were immunohistochemically positive for CD10 and BCL2. Thus, the patient was diagnosed with in situ follicular neoplasm and is currently under observation. In situ follicular neoplasm is typically a slowly progressive neoplasm; however, it can present as a rapidly enlarging pulmonary nodule complicated by pulmonary aspergillosis.
原位滤泡性 B 细胞肿瘤，以前称为原位滤泡性淋巴瘤，是局限于生发中心的滤泡性淋巴瘤样 B 细胞的肿瘤性增生。在此，我们报告 1 例 70 多岁女性，最初表现为多个腹部淋巴结肿大。7 个月后随访时，发现 1 个孤立性肺结节。由于靠近肺门，行肺叶切除术。术中冷冻切片显示纤维化和淋巴细胞及巨噬细胞聚集。因此，对淋巴结进行了取样。站 4 和 10 的淋巴结显示出相似的肿瘤细胞，并对 CD10 和 BCL2 免疫组化阳性。因此，该患者被诊断为原位滤泡性肿瘤，目前正在观察中。原位滤泡性肿瘤通常是一种缓慢进展的肿瘤；然而，它也可以表现为快速增大的肺结节，并伴有肺曲霉病。
