用肿瘤细胞和神经氨酸酶进行肿瘤性疾病的肿瘤治疗。犬乳腺肿瘤棋盘式疫苗接种的进一步实验研究。
Tumor therapy of neoplastic diseases with tumor cells and neuraminidase. Further experimental studies on chessboard vaccination in canine mammary tumors.
作者信息
Sedlacek H H, Hagmayer G, Seiler F R
出版信息
Cancer Immunol Immunother. 1986;23(3):192-9. doi: 10.1007/BF00205649.
Abstract
The therapeutic effect of i.d. injection of tumor cells mixed with Vibrio cholerae neuraminidase (VCN) on tumor progression in dogs with spontaneous mammary tumors was investigated. The i.d. injections were performed in a chessboard-like manner: different numbers (10(5), 10(6), 10(7), and 10(8) of mitomycin-treated autologous tumor cells (M-TC) were each mixed with different amounts (10, 50, and 100 mU) of VCN. These different mixtures were injected i.d. at different sites in dogs on the day of resection of a part of multiple tumors.
摘要
研究了皮下注射与霍乱弧菌神经氨酸酶（VCN）混合的肿瘤细胞对患有自发性乳腺肿瘤的犬肿瘤进展的治疗效果。皮下注射采用棋盘式方式进行：将不同数量（10⁵、10⁶、10⁷和10⁸）的丝裂霉素处理的自体肿瘤细胞（M-TC）分别与不同量（10、50和100 mU）的VCN混合。在切除多个肿瘤的一部分的当天，将这些不同的混合物皮下注射到犬的不同部位。
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