用肿瘤细胞和神经氨酸酶进行肿瘤性疾病的肿瘤治疗。犬乳腺肿瘤棋盘式疫苗接种的进一步实验研究。
Tumor therapy of neoplastic diseases with tumor cells and neuraminidase. Further experimental studies on chessboard vaccination in canine mammary tumors.
作者信息
Sedlacek H H, Hagmayer G, Seiler F R
出版信息
Cancer Immunol Immunother. 1986;23(3):192-9. doi: 10.1007/BF00205649.
Abstract
The therapeutic effect of i.d. injection of tumor cells mixed with Vibrio cholerae neuraminidase (VCN) on tumor progression in dogs with spontaneous mammary tumors was investigated. The i.d. injections were performed in a chessboard-like manner: different numbers (10(5), 10(6), 10(7), and 10(8) of mitomycin-treated autologous tumor cells (M-TC) were each mixed with different amounts (10, 50, and 100 mU) of VCN. These different mixtures were injected i.d. at different sites in dogs on the day of resection of a part of multiple tumors.
摘要
研究了皮下注射与霍乱弧菌神经氨酸酶（VCN）混合的肿瘤细胞对患有自发性乳腺肿瘤的犬肿瘤进展的治疗效果。皮下注射采用棋盘式方式进行：将不同数量（10⁵、10⁶、10⁷和10⁸）的丝裂霉素处理的自体肿瘤细胞（M-TC）分别与不同量（10、50和100 mU）的VCN混合。在切除多个肿瘤的一部分的当天，将这些不同的混合物皮下注射到犬的不同部位。
相似文献
1
Tumor therapy of neoplastic diseases with tumor cells and neuraminidase. Further experimental studies on chessboard vaccination in canine mammary tumors.用肿瘤细胞和神经氨酸酶进行肿瘤性疾病的肿瘤治疗。犬乳腺肿瘤棋盘式疫苗接种的进一步实验研究。
Cancer Immunol Immunother. 1986;23(3):192-9. doi: 10.1007/BF00205649.
2
Tumor therapy of neoplastic diseases with tumor cells and neuraminidase: experimental studies on chessboard vaccination in transplantation tumors.用肿瘤细胞和神经氨酸酶进行肿瘤性疾病的肿瘤治疗：移植瘤棋盘式接种的实验研究
Int J Immunopharmacol. 1987;9(7):841-50. doi: 10.1016/0192-0561(87)90081-6.
3
Experimental cancer immunotherapy: modification of tumor cells to increase immunogenicity.
Ann N Y Acad Sci. 1976;276:45-60. doi: 10.1111/j.1749-6632.1976.tb41635.x.
4
Approaches to effective tumor immunotherapy with cells and the enzyme neuraminidase.
Adv Exp Med Biol. 1979;114:789-94. doi: 10.1007/978-1-4615-9101-6_129.
5
T cell recognition of a tumor-associated glycoprotein and its synthetic carbohydrate epitopes: stimulation of anticancer T cell immunity in vivo.肿瘤相关糖蛋白及其合成碳水化合物表位的T细胞识别：体内抗癌T细胞免疫的刺激
Cancer Immunol Immunother. 1987;25(3):231-41. doi: 10.1007/BF00199152.
6
Antigenicity of Ehrlich ascites through neuraminidase treatment of cells.
Indian J Exp Biol. 1979 Sep;17(9):953-5.
7
Possible immunological action of Vibrio cholerae neuraminidase (VCN) in tumor immunotherapy.霍乱弧菌神经氨酸酶（VCN）在肿瘤免疫治疗中的潜在免疫作用。
Dev Biol Stand. 1977;38:387-98.
8
Differential effect of neuraminidase on the immunogenicity of viral associated and private antigens of mammary carcinomas.
J Immunol. 1973 Dec;111(6):1820-5.
9
10
BCG versus VCN: the antigenicity and the adjuvant effect of both compounds.
Recent Results Cancer Res. 1980;75:53-60. doi: 10.1007/978-3-642-81491-4_9.
引用本文的文献
1
Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager.通过将唾液酸酶融合到双特异性 T 细胞衔接子上来靶向唾液酸化和细胞溶解肿瘤细胞。
Nat Biomed Eng. 2024 May;8(5):499-512. doi: 10.1038/s41551-024-01202-w. Epub 2024 May 1.
2
Enhancing CAR T function with the engineered secretion of C. perfringens neuraminidase.利用工程化分泌的 C. perfringens 神经氨酸酶增强 CAR T 功能。
Mol Ther. 2022 Mar 2;30(3):1201-1214. doi: 10.1016/j.ymthe.2021.11.014. Epub 2021 Nov 20.
3
Spontaneous tumors in dogs and cats: models for the study of cancer biology and treatment.犬猫自发性肿瘤：癌症生物学与治疗研究的模型
Cancer Metastasis Rev. 1990 Sep;9(2):125-36. doi: 10.1007/BF00046339.
本文引用的文献
1
The preparation and properties of two new chromogenic substrates of trypsin.两种新型胰蛋白酶显色底物的制备与性质
Arch Biochem Biophys. 1961 Nov;95:271-8. doi: 10.1016/0003-9861(61)90145-x.
2
The thiobarbituric acid assay of sialic acids.唾液酸的硫代巴比妥酸测定法。
J Biol Chem. 1959 Aug;234(8):1971-5.
3
The reproducibility and constancy of the platelet count.血小板计数的可重复性和稳定性。
Am J Clin Pathol. 1953 Jan;23(1):15-26. doi: 10.1093/ajcp/23.1.15.
4
BCG versus VCN: the antigenicity and the adjuvant effect of both compounds.
Recent Results Cancer Res. 1980;75:53-60. doi: 10.1007/978-3-642-81491-4_9.
5
The Thomsen-Friedenreich (TF) receptor: an old history with new mystery.汤姆森-弗里德赖希（TF）受体：一段有着新谜团的古老历史。
Immunol Commun. 1981;10(3):251-64. doi: 10.3109/08820138109093459.
6
Effect of Vibrio cholerae neuraminidase on the mitogen response of T-lymphocytes. II. Modulation of the lymphocyte response to macrophage released factors by neuraminidase.霍乱弧菌神经氨酸酶对T淋巴细胞有丝分裂原反应的影响。II. 神经氨酸酶对淋巴细胞对巨噬细胞释放因子反应的调节作用。
Immunobiology. 1980 Dec;157(4-5):486-98. doi: 10.1016/S0171-2985(80)80017-9.
7
Effect of Vibrio cholerae neuraminidase on the mitogen response of T lymphocytes. I. Enhancement of macrophage T-lymphocyte cooperation in concanavalin-A-induced lymphocyte activation.霍乱弧菌神经氨酸酶对T淋巴细胞有丝分裂原反应的影响。I. 在刀豆球蛋白A诱导的淋巴细胞活化中增强巨噬细胞与T淋巴细胞的协作。
Immunobiology. 1980 Dec;157(4-5):474-85. doi: 10.1016/S0171-2985(80)80016-7.
8
T antigen, a tumor marker against which breast, lung and pancreas carcinoma patients mount immune responses.
Cancer Detect Prev. 1983;6(1-2):111-8.
9
Intratumoral BCG and Corynebacterium parvum therapy of canine mammary tumours before radical mastectomy.根治性乳房切除术前行瘤内卡介苗和短小棒状杆菌治疗犬乳腺肿瘤
Cancer Immunol Immunother. 1983;15(3):172-7. doi: 10.1007/BF00199160.
10
Coexistence of immunogenic and suppressogenic epitopes in tumor cells and various types of macromolecules.肿瘤细胞和各种类型大分子中免疫原性表位与抑制性表位的共存。
Cancer Immunol Immunother. 1983;16(1):1-10. doi: 10.1007/BF00199898.
Zotero 插件