Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.
Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.
Neurobiol Aging. 2024 Jan;133:51-66. doi: 10.1016/j.neurobiolaging.2023.10.006. Epub 2023 Oct 20.
In the present study we investigated whether hippocampal subfield (cornu ammonis 1-3, dentate gyrus, and subiculum) and anteroposterior hippocampal subregion (head,body, and tail) volumes can predict episodic memory function using high-field high resolution structural magnetic resonance imaging (MRI). We recruited 126 healthy participants (18-85 years). MRI datasets were collected on a 4.7 T system. Participants were administered the Wechsler Memory Scale (WMS-IV) to evaluate episodic memory function. Structural equation modeling was used to test the relationship between studied variables. We found that the volume of the dentate gyrus subfield and posterior hippocampus (body) showed a significant direct effect on visuospatial memory performance; additionally, an indirect effect of age on visuospatial memory mediated through these hippocampal subfield/subregion was significant. Logical and verbal memory were not significantly associated with hippocampal subfield or subregion volumes.
在本研究中，我们使用高磁场高分辨率结构磁共振成像（MRI）来研究海马亚区（CA1-3、齿状回和下托）和前后海马亚区（头、体和尾）体积是否可以预测情景记忆功能。我们招募了 126 名健康参与者（18-85 岁）。MRI 数据集在 4.7T 系统上采集。参与者接受了韦氏记忆量表（WMS-IV）的评估，以评估情景记忆功能。结构方程模型用于测试研究变量之间的关系。我们发现，齿状回亚区和后海马（体）的体积对视觉空间记忆表现有显著的直接影响；此外，年龄对视觉空间记忆的间接影响通过这些海马亚区/亚区是显著的。逻辑和言语记忆与海马亚区或亚区体积没有显著的相关性。
