University of Southern California/Los Angeles General Medical Center, 2051 Marengo Street, Los Angeles, CA 90033, USA.
University of Southern California/Los Angeles General Medical Center, 2051 Marengo Street, Los Angeles, CA 90033, USA; HRC Fertility, 55 S Lake Avenue, Suite 900, Pasadena, CA 91101, USA.
Obstet Gynecol Clin North Am. 2023 Dec;50(4):707-719. doi: 10.1016/j.ogc.2023.08.005. Epub 2023 Sep 7.
Although oocyte cryopreservation was initially used as a fertility preservation strategy for medical indications, it is now is increasingly used to circumvent age-related infertility. Outcomes following planned oocyte vitrification, also known as elective egg freezing, are limited. Current studies show higher success rates for individuals undergoing fertility preservation treatment under age 35. Additionally, while freezing 20 oocytes is optimal to achieve pregnancy, freezing at least 8-10 oocytes is recommended. While fertility is not guaranteed, current evidence demonstrates that planned oocyte vitrification is an overall safe, low risk method of fertility preservation to reduce the risk for age-related infertility.
虽然卵母细胞冷冻保存最初是作为一种医疗适应证的生育力保存策略，但现在它越来越多地被用于规避与年龄相关的不孕。计划中的卵母细胞玻璃化冷冻（也称为选择性卵子冷冻）的结果是有限的。目前的研究表明，35 岁以下接受生育力保存治疗的个体成功率更高。此外，虽然冷冻 20 个卵母细胞是实现妊娠的最佳选择，但建议至少冷冻 8-10 个卵母细胞。虽然生育力不能得到保证，但目前的证据表明，计划中的卵母细胞玻璃化冷冻是一种安全、低风险的生育力保存方法，可以降低与年龄相关的不孕风险。
