Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Front Biosci (Landmark Ed). 2023 Oct 25;28(10):262. doi: 10.31083/j.fbl2810262.
The mammalian intestinal epithelium is a rapidly self-renewing tissue in the body and its homeostasis is tightly controlled by numerous factors at multiple levels. The RNA-binding protein HuR (human antigen R) is intimately involved in many aspects of gut mucosal pathobiology and plays an important role in maintaining integrity of the intestinal epithelium by regulating stability and translation of target mRNAs. Nonetheless, deregulation of HuR expression and altered binding affinity of HuR for target transcripts occur commonly in various gut mucosal disorders. In this review, we highlight the essential role of HuR in the intestinal epithelium homeostasis and discuss recent results that interactions between HuR and noncoding RNAs (ncRNAs), including circular RNAs, long ncRNAs, small vault RNAs, and microRNAs, influence gut mucosal regeneration and regulate barrier function in various pathophysiological conditions. These exciting discoveries advance our knowledge of HuR biological function in the gut mucosa and also create a fundamental basis for developing novel therapies to protect intestinal epithelial integrity in critically ill patients.
哺乳动物的肠道上皮是体内快速自我更新的组织，其稳态受到多层次多种因素的严格控制。RNA 结合蛋白 HuR（人抗原 R）密切参与肠道黏膜病理生物学的许多方面，通过调节靶 mRNA 的稳定性和翻译，在维持肠道上皮完整性方面发挥重要作用。然而，HuR 表达的失调和 HuR 与靶转录本结合亲和力的改变在各种肠道黏膜疾病中很常见。在这篇综述中，我们强调了 HuR 在肠道上皮稳态中的重要作用，并讨论了最近的研究结果，即 HuR 与非编码 RNA（ncRNA）之间的相互作用，包括环状 RNA、长链 ncRNA、小穹窿 RNA 和 microRNA，影响肠道黏膜的再生，并在各种病理生理条件下调节屏障功能。这些令人兴奋的发现促进了我们对 HuR 在肠道黏膜中的生物学功能的认识，也为开发保护危重症患者肠道上皮完整性的新型治疗方法奠定了基础。
