Zhou Jie, Jiang Zhenyu, Li Yunhao, Shao Xuwen, Liao Haihong
Department of Oncology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, China.
Department of Nephrology, The First People's Hospital of Huzhou, First Affiliated Hospital of Huzhou University, Huzhou, China.
Front Oncol. 2023 Oct 18;13:1269118. doi: 10.3389/fonc.2023.1269118. eCollection 2023.
Recently, the survival rate of nasopharyngeal carcinoma (NPC) patients has improved greatly due to developments in NPC treatments. But cause-specific mortality in NPC patients remains unclear. This study aims to investigate the common causes of death in NPC patients.
Eligible patients with NPC were included from the Surveillance, Epidemiology, and End Results (SEER) database. Standardized mortality ratios(SMRs) were calculated to compare death rates in NPC patients with those in the general population.
A total of 3475 patients with NPC were included, of whom 1696 patients died during the follow-up period. 52.83% of deaths were caused by NPC, followed by other cancers (28.13%) and non-cancer causes (18.46%). The proportion of patients who died of NPC decreased over survival time. Moreover, non-cancer causes of death increase from 12.94% to 51.22% over time after 10 years of diagnosis. Heart diseases was the most common non-cancer cause of death in NPC patients.
Although NPC remains the leading cause of death after NPC diagnosis, other non-NPC causes of death represent an increased number of death in NPC patients. These findings support the involvement of multidisciplinary care for follow-up strategy in NPC patients.
近年来，由于鼻咽癌（NPC）治疗方法的发展，NPC患者的生存率有了很大提高。但NPC患者的死因特异性死亡率仍不清楚。本研究旨在调查NPC患者的常见死亡原因。
从监测、流行病学和最终结果（SEER）数据库中纳入符合条件的NPC患者。计算标准化死亡率（SMR），以比较NPC患者与普通人群的死亡率。
共纳入3475例NPC患者，其中1696例患者在随访期间死亡。52.83%的死亡由NPC引起，其次是其他癌症（28.13%）和非癌症原因（18.46%）。死于NPC的患者比例随生存时间下降。此外，诊断10年后，非癌症死亡原因随时间从12.94%增加到51.22%。心脏病是NPC患者最常见的非癌症死亡原因。
虽然NPC仍然是NPC诊断后死亡的主要原因，但其他非NPC死因在NPC患者中的死亡人数有所增加。这些发现支持在NPC患者的随访策略中采用多学科护理。
