Department of Radiotherapy, Shanxi Province Cancer Hospital, Taiyuan, 030000, Shanxi, China.
Department of Radiotherapy, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Taiyuan, 030000, Shanxi, China.
BMC Pulm Med. 2022 Jul 4;22(1):262. doi: 10.1186/s12890-022-02053-4.
To examine the distribution of causes of death (CODs) in patients with small cell lung cancer (SCLC).
Patients diagnosed with SCLC were identified from the Surveillance, Epidemiology, and End Results Program database during 2004-2015. Standardized mortality rates (SMRs) were performed for each COD to present changes in risk for a particular COD following SCLC diagnosis.
A total of 44,506 patients diagnosed with SCLC were identified in this study, and 42,476 patients died during the follow-up. Of total deaths, 69.5% occurred within the first years after diagnosis, 26% occurred from 1 to 3 years, and 4.5% individuals survived longer than 3 years. In addition, 88.7% of deaths were caused by SCLC, followed by non-cancer causes (7.1%) and other cancers (4.2%). Moreover, non-cancer CODs increased from 6.3 to 30% over time after 3 years of diagnosis. As for non-cancer CODs, cardiovascular diseases, COPD, and septicemia were the most common in SCLC.
Non-cancer CODs, such as cardiovascular events, COPD and septicemia, contribute to a considerable proportion of deaths among long-term SCLC survivors, supporting the involvement of multidisciplinary care for the follow-up strategy in SCLC.
研究小细胞肺癌（SCLC）患者的死因分布。
从 2004 年至 2015 年的监测、流行病学和最终结果（SEER）数据库中确定诊断为 SCLC 的患者。对每个死因进行标准化死亡率（SMR），以显示 SCLC 诊断后特定死因的风险变化。
本研究共纳入 44506 例 SCLC 患者，随访期间有 42476 例患者死亡。总死亡中，69.5%发生在诊断后 1 年内，26%发生在 1-3 年内，4.5%的患者存活时间超过 3 年。此外，88.7%的死亡归因于 SCLC，其次是非癌症原因（7.1%）和其他癌症（4.2%）。此外，非癌症死因从诊断后 3 年起，占比从 6.3%增加到 30%。对于非癌症死因，心血管疾病、COPD 和败血症在 SCLC 中最为常见。
心血管事件、COPD 和败血症等非癌症死因在 SCLC 长期幸存者的死亡中占相当大的比例，支持为 SCLC 制定的随访策略中采用多学科护理。
