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一个患有偷窃癖和注意缺陷多动障碍的青少年男孩,接受了哌醋甲酯和胍法辛治疗:一例报告。

An adolescent boy with kleptomania and attention-deficit hyperactivity disorder treated with methylphenidate and guanfacine: A case report.

机构信息

Department of Neuropsychiatry, Hirosaki-Aiseikai Hospital, Hirosaki-shi, Aomori, Japan.

Department of Hospital Pharmacy, Hirosaki-Aiseikai Hospital, Hirosaki-shi, Aomori, Japan.

出版信息

Neuropsychopharmacol Rep. 2023 Dec;43(4):650-653. doi: 10.1002/npr2.12394. Epub 2023 Nov 3.

DOI:10.1002/npr2.12394
PMID:37921065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10739163/
Abstract

We present the case of a patient, a boy of 16 years of age at initial presentation, with kleptomania, an impulse disorder characterized by an impulse to steal unneeded items, and attention-deficit hyperactivity disorder (ADHD). The patient's parents reported that he would frequently impulsively steal items and money that he did not need. Cognitive and physical assessments revealed no abnormalities, and the patient had no history of substance abuse. The patient was diagnosed with kleptomania and ADHD. The patient was started on Osmotic Release Oral System Methylphenidate (OROS-MPH), a medication commonly used to treat ADHD, and experienced improvement in ADHD symptoms and stealing behavior. At 19 years of age, it was discovered that the patient's behavioral symptoms were uncontrolled during times of the day when the blood concentration of MPH was likely to have waned. After starting an additional dose of guanfacine at night, his symptoms during these times of day improved. While existing research is not definitive, there may be a connection between ADHD and kleptomania. Further, there are some reports that treatment of ADHD with MPH also reduced stealing behavior, aligning with our present findings. We discuss the potential mechanisms behind these improvements and further present the first evidence of the efficacy of guanfacine in the treatment of kleptomania.

摘要

我们报告了 1 例病例,患者为 16 岁男孩,首次就诊时患有偷窃癖,这是一种冲动障碍,表现为冲动地偷窃不需要的物品,同时还患有注意力缺陷多动障碍(ADHD)。患者的父母报告说,他经常冲动地偷窃他不需要的物品和金钱。认知和身体评估未发现异常,患者也没有药物滥用史。该患者被诊断为偷窃癖和 ADHD。患者开始服用 Osmotic Release Oral System Methylphenidate(OROS-MPH),这是一种常用于治疗 ADHD 的药物,ADHD 症状和偷窃行为得到改善。19 岁时,发现患者在 MPH 血药浓度可能下降的白天时段,其行为症状无法控制。晚上开始加用胍法辛后,这些时段的症状得到改善。虽然现有研究尚无定论,但 ADHD 和偷窃癖之间可能存在关联。此外,有一些报告称,用 MPH 治疗 ADHD 也可减少偷窃行为,这与我们目前的发现一致。我们讨论了这些改善背后的潜在机制,并进一步提出了胍法辛治疗偷窃癖的首例疗效证据。

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