Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
Antiinflamm Antiallergy Agents Med Chem. 2023;22(4):230-235. doi: 10.2174/0118715230252770231020060606.
Quercetin belongs to the BCS Class IV of drugs, which means it exhibits low solubility and low permeability. Quercetin is a potent antioxidant drug candidate, but it has several drawbacks, such as a short half-life, poor stability, bioavailability, and solubility. These factors affect its reliability as a good wound-healing, anti-inflammatory, and antioxidant agent. Quercetin nanoparticles resolved these problems and offered high stability, high encapsulation efficacy, sustained and prolonged release, and enhanced accumulation at target sites with high therapeutic efficacy.
Banana starch and quercetin were used to formulate a new composition of nanoparticles. Formulated QBSN were evaluated for their antioxidant, wound healing, and anti-inflammatory potential.
QBSN showed a good antioxidant effect against the DPPH free radical scavenging model. Inhibition of DPPH free radicals reached up to 98 percent at 40 μl. Histopathological studies of treated tissues (wound and paw edema) confirmed the potential of QBSN.
In the future, prepared nanoparticles may be the choice of drug formulation for wound healing, anti-inflammatory therapy, and antioxidant therapy.
槲皮素属于 BCS 分类法中的第四类药物，这意味着它表现出低溶解度和低渗透性。槲皮素是一种有效的抗氧化药物候选物，但它有几个缺点，如半衰期短、稳定性差、生物利用度和溶解度低。这些因素影响了它作为一种良好的伤口愈合、抗炎和抗氧化剂的可靠性。槲皮素纳米粒解决了这些问题，并提供了高稳定性、高包封效率、持续和延长释放以及在靶部位的增强积累，从而具有高治疗效果。
香蕉淀粉和槲皮素被用来制备纳米粒的新组合物。所制备的 QBSN 被评估其抗氧化、伤口愈合和抗炎潜力。
QBSN 对 DPPH 自由基清除模型表现出良好的抗氧化作用。在 40μl 时，对 DPPH 自由基的抑制率高达 98%。对治疗组织（伤口和爪水肿）的组织病理学研究证实了 QBSN 的潜力。
在未来，制备的纳米粒可能是用于伤口愈合、抗炎治疗和抗氧化治疗的药物制剂的选择。
