Yang Ming, Chen Wei, He Liyu, Wang Xi, Liu Di, Xiao Li, Sun Lin
Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.
Department of Nutrition, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Curr Med Chem. 2025;32(7):1276-1287. doi: 10.2174/0109298673255403230919061828.
Diabetic nephropathy (DN) has gradually become one of the main causes of end-stage renal disease (ESRD). However, there is still a lack of effective preventive measures to delay its progression. As the energy factory in the cell, mitochondria play an irreplaceable role in maintaining cell homeostasis. Interestingly, recent studies have shown that in addition to maintaining homeostasis in cells in which mitochondria reside, when mitochondrial perturbations occur in one tissue, distal tissues can also sense and act through mitochondrial stress response pathways through a group of proteins or peptides called "mitokines". Here, we reviewed the mitokines that have been found thus far and summarized their research progress in DN. Finally, we explored the possibility of mitokines as potential therapeutic targets for DN.
糖尿病肾病（DN）已逐渐成为终末期肾病（ESRD）的主要病因之一。然而，仍缺乏有效的预防措施来延缓其进展。线粒体作为细胞中的能量工厂，在维持细胞稳态方面发挥着不可替代的作用。有趣的是，最近的研究表明，线粒体除了在其所在细胞中维持稳态外，当一个组织中发生线粒体扰动时，远端组织也可以通过一组称为“线粒体因子”的蛋白质或肽，通过线粒体应激反应途径进行感知和反应。在此，我们综述了迄今为止已发现的线粒体因子，并总结了它们在糖尿病肾病中的研究进展。最后，我们探讨了线粒体因子作为糖尿病肾病潜在治疗靶点的可能性。
