Department of Pharmacology, Girijananda Chowdhury Institute of Pharmaceutical Science, Hatkhowapara Azara, Guwahati, 17, India.
Department of Pharmacognosy, Girijananda Chowdhury Institute of Pharmaceutical Science, Hatkhowapara Azara, Guwahati, 17, India.
Curr Drug Discov Technol. 2024;21(1):e251023222716. doi: 10.2174/0115701638242317231018144944.
The chance of contracting significant diseases increases due to an unhealthy and contemporary lifestyle. Chrysin is a flavonoid of the flavone class in numerous plants, including Passiflora and Pelargonium. Chrysin has long been used to treat a variety of illnesses. Chrysin, an essential flavonoid, has many pharmacological actions, including anticancer, antiviral, anti-inflammatory, anti-arthritic, depressive, hypolipidemic, hepatoprotective, and nephroprotective activity.
This explorative review was commenced to provide a holistic review of flavonoids confirming that Chrysin has a therapeutic potential on the liver and kidney and reduces the hepatotoxicity and nephrotoxicity induced by diverse toxicants, which can be helpful for the toxicologists, pharmacologists, and chemists to develop new safer pharmaceutical products with chrysin and other toxicants.
The most relevant studies that were well-explained and fit the chosen topic best were picked. The achieved information was analyzed to determine the outcome by screening sources by title, abstract, and whole work. Between themselves, the writers decided on the studies to be considered. The necessary details were systematically organized into titles and subtitles and compressively discussed.
The information presented in this review is obtained using targeted searches on several online platforms, including Google Scholar, Scifinder, PubMed, Science Direct, ACS publications, and Wiley Online Library. The works were chosen based on the inclusion criteria agreed upon by all authors.
Chrysin is a promising bioactive flavonoid with significant health benefits, and its synthetic replacements are being utilized as pharmaceuticals to treat various diseases. Findings revealed that Chrysin exhibits hepatoprotective actions against several hepatotoxicants like 2,3,7,8 tetrachlorodibenzo- p-dioxin, carbon tetrachloride (CCl), cisplatin, and others by lowering the levels of liver toxicity biomarkers and enhancing antioxidant levels. Additionally, chrysin has potential nephroprotective properties against various nephrotoxicants, like Cisplatin, Doxorubicin, Paracetamol, Gentamicin, Streptazosin, and others by dropping kidney toxicity marker levels, reducing oxidative stress, and improving the antioxidant level.
According to this revised study, chrysin is a promising phytoconstituent that can be utilized as an alternate treatment for various medications that cause hepatotoxicity and nephrotoxicity. With active chrysin, several dosage forms targeting the liver and kidneys can be formulated.
由于不健康和现代的生活方式，患重大疾病的几率增加。白杨素是许多植物（包括西番莲和天竺葵）中类黄酮的黄酮类化合物。白杨素长期以来一直被用于治疗各种疾病。作为一种必需的类黄酮，白杨素有许多药理作用，包括抗癌、抗病毒、抗炎、抗关节炎、抗抑郁、降血脂、保肝和保肾作用。
本探索性综述旨在全面综述类黄酮，证实白杨素有治疗肝脏和肾脏的潜力，并减轻各种毒物引起的肝毒性和肾毒性，这对毒理学家、药理学家和化学家开发含有白杨素和其他毒物的新的更安全的药物产品将有所帮助。
选择了最相关的、解释充分且最符合所选主题的研究。通过标题、摘要和全文筛选来源，分析所获得的信息以确定结果。作者之间自行决定要考虑的研究。将必要的细节系统地组织成标题和副标题，并进行简明讨论。
本综述中呈现的信息是通过在几个在线平台（包括 Google Scholar、Scifinder、PubMed、Science Direct、ACS 出版物和 Wiley Online Library）上进行有针对性的搜索获得的。根据所有作者同意的纳入标准选择这些作品。
白杨素是一种很有前途的生物活性类黄酮，具有显著的健康益处，其合成替代品被用作药物来治疗各种疾病。研究结果表明，白杨素通过降低肝毒性生物标志物水平和提高抗氧化水平，对 2,3,7,8-四氯二苯并-p-二恶英、四氯化碳（CCl）、顺铂等多种肝毒性物质表现出保肝作用。此外，白杨素有潜在的肾保护作用，可对抗顺铂、阿霉素、扑热息痛、庆大霉素、streptazosin 等多种肾毒性物质，通过降低肾毒性标志物水平、减轻氧化应激和提高抗氧化水平。
根据这项修订后的研究，白杨素是一种很有前途的植物成分，可以作为治疗各种引起肝毒性和肾毒性的药物的替代疗法。通过使用活性白杨素，可以针对肝脏和肾脏开发几种剂型。
