Ramos Islas Josue, Lomelí Manuel López-Cabanillas, González Martínez Blanca Edelia, Ramos Islas Israel Ricardo, López Myriam Gutiérrez, Tijerina-Sáenz Alexandra, Vázquez Rodríguez Jesús Alberto, López Luis Fernando Méndez, Verde-Star María Julia, García-Ponce Romario, García-Hernández David Gilberto, Heya Michel Stéphane
Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Ave. Pedro de Alba S/N & Ave. Manuel L. Barragán, San Nicolás de los Garza 64460, NL, Mexico.
Facultad de Medicina, Universidad Autónoma de Nuevo León, Pedro de Alba S/N & Ave. Manuel L. Barragán, San Nicolás de los Garza 64460, NL, Mexico.
Int J Mol Sci. 2025 Sep 4;26(17):8619. doi: 10.3390/ijms26178619.
Kidney diseases represent an increasingly significant global public health challenge, with an estimated prevalence of around 10% among adults and a rising trend influenced by factors such as population aging and exposure to nephrotoxic agents. Given the limitations of conventional treatments, which often only slow disease progression and may cause adverse effects, there is growing interest in exploring alternative therapies based on natural compounds. , commonly known for its ornamental use, has been widely used in traditional medicine in Mexico and other tropical regions due to its antioxidant, anti-inflammatory, and regenerative properties. Recently, its phytochemical profile has drawn scientific attention, particularly due to its high content of hydroxylated aromatic compounds such as flavonoids, terpenes, and phenolic acids, which may offer protective effects on kidney function. For this review, searches were conducted in specialized databases such as PubMed, Scopus, and Google Scholar, as well as platforms like ChEMBL and SWISS, selecting articles published between 2008 and 2025. This work aims to compile and critically analyze the available scientific literature on the nephroprotective potential of the phytochemicals found in , and includes a preliminary exploration of their possible mechanisms of action using pharmacokinetic and pharmacodynamic prediction tools.
肾脏疾病是一个日益严峻的全球公共卫生挑战，据估计，成年人中的患病率约为10%，且受人口老龄化和接触肾毒性物质等因素影响呈上升趋势。鉴于传统治疗方法存在局限性，往往只能延缓疾病进展且可能产生不良反应，人们对探索基于天然化合物的替代疗法的兴趣日益浓厚。 ，通常因其观赏用途而闻名，由于其具有抗氧化、抗炎和再生特性，已在墨西哥和其他热带地区的传统医学中广泛使用。最近，其植物化学特征引起了科学关注，特别是因其富含黄酮类、萜类和酚酸等羟基化芳香化合物，这些化合物可能对肾脏功能具有保护作用。在本次综述中，我们在PubMed、Scopus和谷歌学术等专业数据库以及ChEMBL和SWISS等平台上进行了检索，选择了2008年至2025年发表的文章。这项工作旨在汇编和批判性分析关于 中发现的植物化学物质的肾保护潜力的现有科学文献，并使用药代动力学和药效学预测工具对其可能的作用机制进行初步探索。
