Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Ozark Veterinary Specialty Care, 881 Animal Emergency Dr, Springdale, Arkansas, USA.
J Vet Intern Med. 2024 Jan-Feb;38(1):176-186. doi: 10.1111/jvim.16922. Epub 2023 Nov 3.
Information is limited regarding the prevalence and importance of hepatic histologic abnormalities in dogs with gallbladder mucocele (GBM).
To (a) report prevalence of hepatic histologic abnormalities in dogs with GBM (b) evaluate for association between hepatic abnormalities and outcome in dogs with GBM (c) evaluate whether neutrophil-to-lymphocyte ratio (NLR) differs in dogs with GBM with and without specific hepatic lesions.
Fifty-two dogs with grossly and histologically confirmed GBM.
Multicenter, retrospective study of dogs with GBM undergoing cholecystectomy with concurrent liver biopsy. Archived histological sections of gallbladder and liver evaluated by investigators blinded to data. Proportions of dogs with each histologic abnormality alive vs deceased at 1, 3, and 12 months post-cholecystectomy compared. Mann-Whitney U performed to determine if NLR differed in dogs with or without selected lesions.
51/52 (98%, 95% CI [89%, 99%]) dogs with GBM had at least 1 hepatic histologic abnormality. Hepatic fibrosis (37/51; 73%, 95% CI [59%, 83%]), biliary hyperplasia (29/52; 56%, 95% CI [42%, 68%]), and portal inflammation (25/52; 48%, 95% CI [35%, 61%]) were most common. The proportion of dogs alive vs dead differed based on the fibrosis score at 1, 3, and 12 (P ≤ .04) months post-cholecystectomy. Dogs with hepatic necrosis (P = .006) and cholangitis/cholangiohepatitis (P = .02) had higher NLRs compared to dogs without these lesions.
Histologic abnormalities of the liver are common in dogs with GBM. A higher portal fibrosis score might be associated with shortened long-term survival after cholecystectomy for dogs with GBM. An increase in NLR might predict hepatic necrosis and cholangitis/cholangiohepatitis in dogs with GBM.
有关胆囊黏液囊肿（GBM）犬肝脏组织学异常的流行率和重要性的信息有限。
（a）报告 GBM 犬肝脏组织学异常的流行率；（b）评估 GBM 犬肝脏异常与结局之间的关系；（c）评估中性粒细胞与淋巴细胞比值（NLR）在有无特定肝脏病变的 GBM 犬中是否存在差异。
52 只经大体和组织学证实患有 GBM 的犬。
对接受胆囊切除术和同期肝活检的 GBM 犬进行多中心回顾性研究。由对数据不知情的研究者评估存档的胆囊和肝脏组织学切片。比较胆囊切除术 1、3 和 12 个月后存活和死亡犬的每种组织学异常比例。采用 Mann-Whitney U 检验确定 NLR 是否在有或无特定病变的犬中存在差异。
52 只 GBM 犬中（98%，95%CI [89%，99%]）至少有 1 只肝脏组织学异常。肝纤维化（37/51；73%，95%CI [59%，83%]）、胆管增生（29/52；56%，95%CI [42%，68%]）和门静脉炎症（25/52；48%，95%CI [35%，61%]）最常见。胆囊切除术 1、3 和 12 个月后（P≤0.04），存活犬与死亡犬的比例不同。与无这些病变的犬相比，有肝坏死（P=0.006）和胆管炎/胆管肝炎（P=0.02）的犬 NLR 更高。
GBM 犬的肝脏组织学异常很常见。较高的门静脉纤维化评分可能与 GBM 犬胆囊切除术后长期生存缩短有关。NLR 的增加可能预测 GBM 犬的肝坏死和胆管炎/胆管肝炎。
