College of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China; Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, Hunan, China.
Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, Hunan, China.
Life Sci. 2023 Dec 1;334:122229. doi: 10.1016/j.lfs.2023.122229. Epub 2023 Nov 1.
Low-grade chronic inflammation, also known as metabolic inflammation, promotes the development of metabolic diseases. Increasing evidence suggests that changes in gut microbes and metabolites disrupt the integrity of the gut barrier and exert significant effects on the metabolism of various tissues, including the liver and adipose tissue, thereby contributing to metabolic inflammation. We observed that IL-22 is a key signaling molecule that serves as a bridge between intestinal microbes and the host, effectively alleviating metabolic inflammation by modulating the host immunomodulatory network. Here, we focused on elucidating the underlying mechanisms by which the gut microbiota and their metabolites reduce inflammation via IL-22, highlighting the favorable impact of IL-22 on metabolic inflammation. Furthermore, we discuss the potential of IL-22 as a therapeutic target for the management of metabolic inflammation and related diseases.
低度慢性炎症，也称为代谢性炎症，促进了代谢性疾病的发展。越来越多的证据表明，肠道微生物和代谢物的变化破坏了肠道屏障的完整性，并对包括肝脏和脂肪组织在内的各种组织的代谢产生重大影响，从而导致代谢性炎症。我们观察到，IL-22 是一种关键的信号分子，充当肠道微生物和宿主之间的桥梁，通过调节宿主免疫调节网络，有效缓解代谢性炎症。在这里，我们专注于阐明肠道微生物及其代谢物通过 IL-22 减轻炎症的潜在机制，突出了 IL-22 对代谢性炎症的有利影响。此外，我们还讨论了 IL-22 作为治疗代谢性炎症和相关疾病的潜在靶点的可能性。
