Department of Medical Oncology, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India
Department of Medical Oncology, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
BMJ Case Rep. 2023 Nov 3;16(11):e255021. doi: 10.1136/bcr-2023-255021.
Intestinal-type sinonasal adenocarcinoma is a rare epithelial malignancy primarily treated with surgery and chemoradiation. The combination of low-dose immunotherapy and a tyrosine kinase inhibitor in recurrent disease has not been previously studied.A man in his 20s with papillary adenocarcinoma of the sinonasal region, following surgical resection, was treated with six cycles of concurrent chemoradiotherapy, followed by four cycles of docetaxel, cisplatin and capecitabine. While on treatment, he was found to have extensive residual disease and he was started on low-dose nivolumab and cabozantinib. Repeat imaging after ten months of treatment revealed a significant reduction in lesions.Non-squamous head and neck cancers are often excluded from major trials, and the effect of immunotherapy in these histologies is poorly understood. The response seen with low-dose immunotherapy underscores the need for further research in this setting.
肠型鼻腔鼻窦腺癌是一种罕见的上皮恶性肿瘤，主要采用手术和放化疗治疗。在复发性疾病中联合应用低剂量免疫治疗和酪氨酸激酶抑制剂此前尚未进行研究。一位 20 多岁的男性患有鼻腔鼻窦区域的乳头状腺癌，在手术后接受了六周期同步放化疗，随后接受了四周期多西紫杉醇、顺铂和卡培他滨治疗。在治疗过程中，他被发现有广泛的残留疾病，开始接受低剂量纳武单抗和卡博替尼治疗。治疗十个月后的重复影像学检查显示病变明显缩小。非鳞状头颈部癌症通常被排除在主要临床试验之外，免疫治疗在这些组织学中的效果知之甚少。低剂量免疫治疗的反应强调了在这一领域进一步研究的必要性。
