Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China.
Department of Cardiology, The Affiliated Hospital of Shaoxing University, Shaoxing, People's Republic of China.
BMC Cardiovasc Disord. 2023 Nov 4;23(1):537. doi: 10.1186/s12872-023-03575-3.
To observe the efficacy and safety of self-made covered coronary stent in the treatment of coronary artery perforation.
Covered coronary stent was prepared by wrapping 3 M film on the surface of coronary stents. The beagle dogs were divided into control group and experimental group. A drug-eluting stent (DES) was implanted in the control group. The covered stent was applied to block the coronary branches of beagle dogs. The CaIMR value after stent placement was calculated by FlashAngio software. The effect of blocking the coronary branches on blood flow was observed by coronary angiography (CAG). The condition of the implanted stent was observed by optical coherence tomography (OCT), and the histopathologic examination of the coronary vessel implanted stent was performed by HE staining.
The best number of layers was 2. Compared with the control group, the CaIMR of the experimental group increased (p < 0.05). A lot of in-stent thrombosis were found in the experimental group and obvious blood flow obstruction during follow-up. HE staining showed that stents implanted in the two groups adhered well to the wall of the blood vessel, but in-stent thrombosis and intimal hyperplasia were founded in the experimental group, while the in-stent restenosis was not founded.
The self-made coronary covered stent can effectively block the leakage caused by coronary perforation, but the stent endothelialization is poor, which easily causes stent thrombosis and restenosis, so it is not recommended as a routine remedy.
观察自制带膜冠状动脉支架治疗冠状动脉穿孔的疗效及安全性。
采用在冠状动脉支架表面包裹 3M 贴膜的方法自制带膜冠状动脉支架。将杂种犬分为对照组和实验组，对照组植入药物洗脱支架（DES），实验组应用带膜支架封堵杂种犬冠状动脉分支，通过 FlashAngio 软件计算支架放置后 CaIMR 值，通过冠状动脉造影（CAG）观察支架封堵冠状动脉分支对血流的影响，通过光学相干断层扫描（OCT）观察植入支架的情况，并对冠状动脉植入支架行 HE 染色行病理组织学检查。
最佳包绕层数为 2 层，实验组 CaIMR 较对照组增加（p < 0.05）。实验组支架内血栓形成较多，随访过程中发现明显的血流阻塞。HE 染色显示两组支架均与血管壁黏附良好，但实验组发现支架内血栓形成和内膜增生，而未发现支架内再狭窄。
自制冠状动脉带膜支架能有效封堵冠状动脉穿孔所致的漏口，但支架内皮化不良，容易导致支架内血栓形成和再狭窄，不推荐作为常规补救措施。
