Jones W N, Kern K B, Rindone J P, Mayersohn M, Bliss M, Goldman S
Eur J Clin Pharmacol. 1986;31(3):351-3. doi: 10.1007/BF00981136.
The pharmacokinetics of digoxin were studied before and after a 2 week course of diltiazem, 30 mg four times daily, in 7 healthy volunteers. Each subject received an IV dose of digoxin before starting diltiazem and again on day 15 of the study. Diltiazem was continued until all sera and urine were collected. During the control and diltiazem phases, respectively, the terminal elimination rate constants were 0.0231 +/- 0.007 h-1 and 0.0254 +/- 0.007 h-1, the volumes of distribution were 10.5 +/- 3.95 l/kg and 10.2 +/- 3.26 l/kg, and the total body clearances were 3.72 +/- 0.78 ml X min-1 X kg-1 and 4.09 +/- 0.94 ml X min-1 X kg-1. None of these pharmacokinetic parameters of digoxin were significantly different before or during diltiazem administration. Overall, there does not appear to be an interaction between digoxin and diltiazem.
在7名健康志愿者中，研究了地尔硫䓬（每日4次，每次30毫克，疗程2周）治疗前后地高辛的药代动力学。在开始使用地尔硫䓬前及研究的第15天，每名受试者均接受静脉注射一剂地高辛。地尔硫䓬持续使用至所有血清和尿液采集完毕。在对照期和地尔硫䓬治疗期，终末消除速率常数分别为0.0231±0.007 h⁻¹和0.0254±0.007 h⁻¹，分布容积分别为10.5±3.95升/千克和10.2±3.26升/千克，总体清除率分别为3.72±0.78毫升·分钟⁻¹·千克⁻¹和4.09±0.94毫升·分钟⁻¹·千克⁻¹。地高辛的这些药代动力学参数在使用地尔硫䓬前和用药期间均无显著差异。总体而言，地高辛和地尔硫䓬之间似乎不存在相互作用。
Zotero 插件