Yoshida A, Fujita M, Kurosawa N, Nioka M, Shichinohe T, Arakawa M, Fukuda R, Owada E, Ito K
Clin Pharmacol Ther. 1984 May;35(5):681-5. doi: 10.1038/clpt.1984.95.
To evaluate a possible effect of diltiazem hydrochloride (DTZ) on digoxin (DX) kinetics, we performed a study in which a single oral dose of DX (0.5 or 0.75 mg) was given with and without DTZ (30 mg three times daily for 1 wk) to six healthy subjects. DTZ increased plasma DX concentrations at 3, 4, 6, and 12 hr and decreased renal clearance of DX from 3.05 +/- 0.126 to 2.31 +/- 0.234 ml/min/kg. There was no significant change in absorption t 1/2, peak concentration, peak concentration time, distribution t 1/2, biologic elimination t 1/2, or apparent volume of distribution with DTZ.
为评估盐酸地尔硫䓬（DTZ）对地高辛（DX）动力学的可能影响，我们开展了一项研究，对6名健康受试者给予单次口服剂量的DX（0.5或0.75毫克），给药时分别联合及不联合DTZ（每日3次，每次30毫克，共1周）。DTZ使3、4、6和12小时时的血浆DX浓度升高，并使DX的肾脏清除率从3.05±0.126降至2.31±0.234毫升/分钟/千克。联合DTZ时，吸收半衰期、峰浓度、峰浓度时间、分布半衰期、生物消除半衰期或表观分布容积均无显著变化。
