硝苯地平对健康受试者地高辛动力学的影响。

Effect of nifedipine on digoxin kinetics in healthy subjects.

作者信息

Pedersen K E, Dorph-Pedersen A, Hvidt S, Klitgaard N A, Kjaer K, Nielsen-Kudsk F

出版信息

Clin Pharmacol Ther. 1982 Nov;32(5):562-5. doi: 10.1038/clpt.1982.203.

DOI:10.1038/clpt.1982.203

Abstract

Verapamil has been shown to reduce total-body digoxin clearance by 35% due to impairments of both renal and extrarenal clearances. Our study was undertaken to evaluate the influence of the related calcium antagonist nifedipine on single-dose kinetics. Nifedipine increased extrarenal clearance of digoxin from 1.09 +/- 0.30(SD) to 1.45 +/- 0.23 ml/min/kg (P less than 0.05) and reduced the total urinary recovery of the drug from 69.2% +/- 5.9(SD) to 64.3% +/- 5.2 (P less than 0.05). There were no significant changes in renal digoxin clearance, distribution, or biological half-life or in digoxin distribution volumes during nifedipine coadministration.

摘要

维拉帕米已被证明可使地高辛的全身清除率降低35%，这是由于肾清除率和肾外清除率均受损。我们进行这项研究以评估相关钙拮抗剂硝苯地平对单剂量动力学的影响。硝苯地平使地高辛的肾外清除率从1.09±0.30（标准差）提高到1.45±0.23 ml/（min·kg）（P<0.05），并使该药物的总尿回收率从69.2%±5.9（标准差）降至64.3%±5.2（P<0.05）。在合用硝苯地平期间，地高辛的肾清除率、分布、生物半衰期或分布容积均无显著变化。