Deetz T R, Evans D J, Evans D G, DuPont H L
J Infect Dis. 1979 Jul;140(1):114-8. doi: 10.1093/infdis/140.1.114.
To improve the retrospective diagnoses of enterotoxigenic Escherichia coli (ETEC) as a cause of travelers' diarrhea, as well as to determine the presence of colonization-factor antigens in these infections, a study of serologic responses to antigens of ETEC was done. Paired sera from 60 United States students in Cholula, Puebla, Mexico, were analyzed for rises in titer of antibody to heat-labile toxin, eight somatic antigen O serogroups associated with ETEC, and two colonization-factor antigens, CFA/I and CFA/II. Only 9% had a response to O antigens, while 20% had responses to the colonization-factor antigens. Response to the colonization-factor antigens correlated significantly with response to the heat-labile toxin and with culture evidence of ETEC infection. Serologic studies confirmed that colonization-factor antigen has a role in naturally acquired cases of travelers' diarrhea and that it can be used as an additional determinant of infection with ETEC.
为了改进对产肠毒素大肠杆菌（ETEC）作为旅行者腹泻病因的回顾性诊断，并确定这些感染中定居因子抗原的存在情况，开展了一项针对ETEC抗原血清学反应的研究。对来自墨西哥普埃布拉州乔卢拉的60名美国学生的配对血清进行了分析，以检测针对不耐热毒素、与ETEC相关的8个菌体抗原O血清群以及两种定居因子抗原CFA/I和CFA/II的抗体滴度升高情况。只有9%的人对O抗原产生反应，而20%的人对定居因子抗原产生反应。对定居因子抗原的反应与对不耐热毒素的反应以及ETEC感染的培养证据显著相关。血清学研究证实，定居因子抗原在旅行者腹泻的自然感染病例中起作用，并且可作为ETEC感染的一个额外判定指标。
