Clemens J D, Svennerholm A M, Harris J R, Huda S, Rao M, Neogy P K, Khan M R, Ansaruzzaman M, Rahaman S, Ahmed F
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
J Infect Dis. 1990 Aug;162(2):448-53. doi: 10.1093/infdis/162.2.448.
To evaluate serologic immunity against clinical infections by heat-labile enterotoxin-producing Escherichia coli (LT-ETEC) in rural Bangladesh, 124 children and adult women with LT-ETEC diarrhea (cases) were compared with 347 age-matched community controls. In paired acute-convalescent sera from the cases, IgG anti-CFA I and anti-CFA II antibody titers increased eight-to ninefold after infection by LT-ETEC with the homologous CFA, and IgG anti-LT antibody titers increased fourfold for all LT-ETEC infections. Anti-CFA and anti-LT titers peaked in controls aged 12-23 months, the age group with the highest incidence of ETEC infections. However, antibody titers were similar in acute sera from cases and in sera from controls. Although serum IgG anti-CFA and anti-LT antibodies rose in response to LT-ETEC infections and paralleled the age-specific incidence of ETEC in the community, these antibodies were not associated with a lower risk of LT-ETEC diarrhea.
为评估孟加拉国农村地区针对产不耐热肠毒素大肠杆菌（LT-ETEC）临床感染的血清学免疫力，将124例患有LT-ETEC腹泻的儿童和成年女性（病例）与347名年龄匹配的社区对照进行了比较。在病例的配对急性-恢复期血清中，感染同源CFA的LT-ETEC后，IgG抗CFA I和抗CFA II抗体滴度增加了八至九倍，而所有LT-ETEC感染的IgG抗LT抗体滴度增加了四倍。抗CFA和抗LT滴度在12至23个月龄的对照中达到峰值，该年龄组是ETEC感染发病率最高的年龄组。然而，病例急性血清中的抗体滴度与对照血清中的抗体滴度相似。尽管血清IgG抗CFA和抗LT抗体因LT-ETEC感染而升高，且与社区中ETEC的年龄特异性发病率平行，但这些抗体与LT-ETEC腹泻风险较低无关。
