Aier Eye Hospital of Wuhan University (Wuhan Aier Eye Hospital), Wuhan, China.
Sci Rep. 2023 Nov 4;13(1):19099. doi: 10.1038/s41598-023-46502-4.
To assess the effect of sodium fluorescein (NaF) strip on corneal parameters commonly used in Laser-assisted in-situ keratomileusis (LASIK). Eighty-six subjects (172 eyes) scheduled for LASIK were recruited between January and March 2022. The study and statistical analysis test were conducted in April 2022. Topographic measurements of corneal parameters, including central corneal thickness (CCT), anterior keratometric (K) readings (K1, flat keratometry; K2, steep keratometry), horizontal corneal diameter (white to white, WTW), and corneal asphericity (Q value), were obtained using a Scheimpflug device (Pentacam) before and 10 min after NaF strip treatmentThe Pentacam recorded a small significant increase in CCT (mean 538.88 ± 28.78 μm to 547.90 ± 29.94 μm; p < .001), with no differences in K1 and K2 (mean 42.24 ± 1.35D to 42.24 ± 1.35D, and mean 43.34 ± 1.50D to 43.32 ± 1.51D; P > .05, for all) as well as WTW(mean 11.58 ± 0.32 mm to 11.58 ± 0.32 mm, P > .05) before and after NaF strip intervention. Furthermore, there was no significant difference was observed in Q value (mean - 0.30 ± 0.13 to - 0.30 ± 0.14, P > .05). These results indicate that clinicians should avoid NaF strip application before obtaining precise topographic measurements of cornea parameters using the Pentacam.
评估钠荧光素（NaF）条对用于激光辅助原位角膜磨镶术（LASIK）的角膜参数的影响。2022 年 1 月至 3 月期间，招募了 86 名（172 只眼）计划接受 LASIK 的受试者。该研究和统计分析测试于 2022 年 4 月进行。使用 Scheimpflug 设备（Pentacam）在 NaF 条处理前和处理后 10 分钟测量角膜参数的地形图，包括中央角膜厚度（CCT）、前角膜曲率（K1，平坦角膜曲率；K2，陡峭角膜曲率）、水平角膜直径（白到白，WTW）和角膜非球面性（Q 值）。Pentacam 记录 CCT 有小但显著的增加（平均值 538.88±28.78μm 至 547.90±29.94μm；p<0.001），K1 和 K2 无差异（平均值 42.24±1.35D 至 42.24±1.35D，和平均值 43.34±1.50D 至 43.32±1.51D；P>0.05，均）以及 WTW（平均值 11.58±0.32mm 至 11.58±0.32mm，P>0.05）在 NaF 条干预前后。此外，Q 值没有观察到显著差异（平均值-0.30±0.13 至-0.30±0.14，P>0.05）。这些结果表明，临床医生应避免在使用 Pentacam 获得角膜参数的精确地形测量之前应用 NaF 条。
