Centre of Molecular and Macromolecular Studies Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.
Centre of Molecular and Macromolecular Studies Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.
Colloids Surf B Biointerfaces. 2024 Jan;233:113609. doi: 10.1016/j.colsurfb.2023.113609. Epub 2023 Oct 21.
Novel poly(ethylene 2,5-furandicarboxylate) PEF nonwovens were produced by solution electrospinning and further modification. To improve the wettability of the hydrophobic nonwovens with water, they were treated with sodium hydroxide. Cytotoxicity tests carried out with human keratinocytes confirmed that the nonwovens did not have a toxic effect on healthy cells. The hydrophilicity of the sodium hydroxide treated nonwoven favored the adherence of the cells and their growth. In turn, the two-step modification of the nonwovens by reactions with (3-mercaptopropyl)methyldimethoxysilane and silver nitrate permitted to deposit silver particles on the fiber surfaces. The bacteria growth inhibition zones around the tested specimens were observed evidencing their antibacterial activity against Escherichia coli and Staphylococcus aureus.
新型聚（2,5-呋喃二甲酸乙二酯）PEF 非织造布通过溶液静电纺丝和进一步改性制备。为了提高疏水性非织造布对水的润湿性，用氢氧化钠对其进行处理。用人角质细胞进行的细胞毒性试验证实，非织造布对健康细胞没有毒性作用。氢氧化钠处理过的非织造布的亲水性有利于细胞的附着和生长。反过来，通过与（3-巯丙基）甲基二甲氧基硅烷和硝酸银的两步反应对非织造布进行改性，允许在纤维表面沉积银颗粒。在测试样本周围观察到细菌生长抑制区，证明它们对大肠杆菌和金黄色葡萄球菌具有抗菌活性。
