Huang Y, Gao S, Li Y
Nanshan District Center for Disease Control and Prevention, Shenzhen, Guangdong 518054, China.
Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong 518055, China.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2023 Sep 25;35(4):424-426. doi: 10.16250/j.32.1374.2023105.
A patient with fever, chills, and pancytopenia as major clinical manifestations was presented. To investigate the cause, the patient's peripheral blood was collected for pathogen screening using metagenomic next - generation sequencing (mNGS). The DNA sequence of was detected, and amastigotes were found in bone marrow smears using microscopy. The case was therefore definitively diagnosed as visceral leishmaniasis, and was cured and discharged from hospital following treatment with liposomal amphotericin B for 14 days. This is the first imported case of visceral leishmaniasis since the founding of Shenzhen City in 1979.
本文报告了一名以发热、寒战和全血细胞减少为主要临床表现的患者。为明确病因，采集该患者外周血，采用宏基因组下一代测序（mNGS）进行病原体筛查。检测到[病原体名称]的DNA序列，并通过显微镜检查在骨髓涂片中发现了[病原体形态]无鞭毛体。该病例最终被确诊为内脏利什曼病，经脂质体两性霉素B治疗14天后治愈出院。这是深圳市自1979年建市以来首例输入性内脏利什曼病病例。
