Bourrouillou G, Colombies P, Dastugue N
Hum Genet. 1986 Dec;74(4):399-401. doi: 10.1007/BF00280493.
Two thousand one hundred and thirty six couples with one or more spontaneous abortions (SAB) before 13 weeks of gestation and with or without one normal liveborn child (NLC) were karyotyped. In 4.31% of the couples one partner was a carrier of a major chromosomal abnormality. Couples with SAB only have 2-fold more chromosomal aberrations than couples with SAB and NLC. A correlation between the frequency of chromosomal abnormalities and the number of SAB was observed. Finally, the various types of chromosome aberrations were analysed.
对2136对在妊娠13周前有一次或多次自然流产（SAB）且有或没有一个正常活产儿（NLC）的夫妇进行了染色体核型分析。在4.31%的夫妇中，一方是主要染色体异常的携带者。仅有自然流产的夫妇的染色体畸变比有自然流产和正常活产儿的夫妇多两倍。观察到染色体异常频率与自然流产次数之间存在相关性。最后，对各种类型的染色体畸变进行了分析。
