Department of Orthopedics, The Second Central Hospital of Baoding, Zhuozhou City, Hebei Province, P.R. China.
Gastrointestinal Rehabilitation Center, Beijing Rehabilitation Hospital Affiliated to Capital Medical University, Badachu Xixia Zhuang, Shijingshan District, Beijing, P.R. China.
Medicine (Baltimore). 2023 Nov 3;102(44):e35680. doi: 10.1097/MD.0000000000035680.
Vertebral osteoporotic fracture is a common type of fracture, and the incidence is higher in the elderly. However, the relationship between vertebral osteoporotic fractures and interleukin-8 (IL-8) remains unclear. A total of 163 patients with osteoporotic vertebral fractures were recruited. Clinical and follow-up data were recorded, and the expression levels of IL1, MMP9, IL-8, and C-reactive protein in blood were measured. Pearson Chi-square test and Spearman correlation coefficient were used to analyze the relationship between vertebral osteoporotic fractures and related parameters. Univariate and multivariate logistic regression and univariate and multivariate Cox proportional hazards regression were used for further analysis. Pearson chi-square test, Spearman correlation coefficient and Logistic regression analysis showed that IL1 and IL-8 were significantly associated with vertebral osteoporotic fractures. Univariate Cox regression analysis showed that age and IL-8 expression level were significantly associated with maintenance time from recovery to recurrence of vertebral osteoporotic fractures. Multivariate Cox regression analysis showed that IL-8 expression level was significantly associated with maintenance time from recovery to recurrence of vertebral osteoporotic fractures. The higher the expression level of IL-8, the more likely it is to develop vertebral osteoporotic fracture, and the more likely it is to relapse in a short time.
椎体骨质疏松性骨折是一种常见的骨折类型，在老年人中发病率更高。然而，椎体骨质疏松性骨折与白细胞介素-8（IL-8）之间的关系尚不清楚。共招募了 163 名骨质疏松性椎体骨折患者。记录了临床和随访数据，并测量了血液中 IL1、MMP9、IL-8 和 C 反应蛋白的表达水平。采用 Pearson Chi-square 检验和 Spearman 相关系数分析椎体骨质疏松性骨折与相关参数之间的关系。采用单因素和多因素 logistic 回归以及单因素和多因素 Cox 比例风险回归进行进一步分析。Pearson Chi-square 检验、Spearman 相关系数和 Logistic 回归分析表明，IL1 和 IL-8 与椎体骨质疏松性骨折明显相关。单因素 Cox 回归分析表明，年龄和 IL-8 表达水平与椎体骨质疏松性骨折恢复后复发的维持时间明显相关。多因素 Cox 回归分析表明，IL-8 表达水平与椎体骨质疏松性骨折恢复后复发的维持时间明显相关。IL-8 表达水平越高，越容易发生椎体骨质疏松性骨折，且短期内复发的可能性越大。
