Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran.
Life Sci. 2022 Nov 15;309:120984. doi: 10.1016/j.lfs.2022.120984. Epub 2022 Sep 20.
Urological cancers include bladder, prostate and renal cancers that can cause death in males and females. Patients with urological cancers are mainly diagnosed at an advanced disease stage when they also develop resistance to therapy or poor response. The use of natural products in the treatment of urological cancers has shown a significant increase. Curcumin has been widely used in cancer treatment due to its ability to trigger cell death and suppress metastasis. The beneficial effects of curcumin in the treatment of urological cancers is the focus of current review. Curcumin can induce apoptosis in the three types of urological cancers limiting their proliferative potential. Furthermore, curcumin can suppress invasion of urological cancers through EMT inhibition. Notably, curcumin decreases the expression of MMPs, therefore interfering with urological cancer metastasis. When used in combination with chemotherapy agents, curcumin displays synergistic effects in suppressing cancer progression. It can also be used as a chemosensitizer. Based on pre-clinical studies, curcumin administration is beneficial in the treatment of urological cancers and future clinical applications might be considered upon solving problems related to the poor bioavailability of the compound. To improve the bioavailability of curcumin and increase its therapeutic index in urological cancer suppression, nanostructures have been developed to favor targeted delivery.
泌尿系统癌症包括膀胱癌、前列腺癌和肾癌，这些癌症可导致男性和女性死亡。泌尿系统癌症患者主要在疾病晚期被诊断出来，此时他们也会对治疗产生耐药性或反应不佳。在治疗泌尿系统癌症中使用天然产品的情况显著增加。由于姜黄素能够触发细胞死亡并抑制转移，因此已广泛用于癌症治疗。姜黄素在治疗泌尿系统癌症中的有益作用是当前综述的重点。姜黄素可诱导三种类型的泌尿系统癌症细胞凋亡，从而限制其增殖潜力。此外，姜黄素可以通过 EMT 抑制来抑制泌尿系统癌症的侵袭。值得注意的是，姜黄素可降低 MMPs 的表达，从而干扰泌尿系统癌症的转移。当与化疗药物联合使用时，姜黄素在抑制癌症进展方面显示出协同作用。它还可以用作化疗增敏剂。基于临床前研究，姜黄素的给药对泌尿系统癌症的治疗有益，在解决与该化合物生物利用度差相关的问题后，未来可能会考虑将其用于临床应用。为了提高姜黄素的生物利用度并提高其在抑制泌尿系统癌症方面的治疗指数，可以开发纳米结构来促进靶向递送。
