Hamadouk Riham M, Alshareif Einass Mahmoud, Hamad Huda M, Yousef Bashir A
Department of Clinical Pharmacy, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Almughtaribeen University, Khartoum, Sudan.
Drug Healthc Patient Saf. 2023 Nov 1;15:149-157. doi: 10.2147/DHPS.S436458. eCollection 2023.
Multiple drug therapies are commonly used to achieve a desired therapeutic goal, especially in hospitalized patients. However, drug-drug interactions might occur and threaten the patients' safety.
This study aims to assess the prevalence and severity of potential drug-drug interactions (PDDIs) in the internal medicine ward at Soba Teaching Hospital.
A retrospective cross-sectional hospital-based study was carried out in the internal medicine ward at Soba Teaching Hospital from June 2021 to December 2021. The data was collected from patients' medical records. PDDIs were identified using Lexicomp drug interaction software.
A total of 377 patients were included in this study, and overall prevalence of PDDIs was 62.9%. We have identified 989 potential DDIs and 345 pairs of interacting drugs, the mean of the PDDIs per patient was 4.17 ± 4.079. Among 345 PDDIs most were of moderate interactions 70.1% (n=242) followed by Minor interactions 19.1% (n=66). The most common type of interaction was of category C representing 63.5% (n=219). A significant association was observed between the occurrence of PDDIs with patients' age, presence of chronic diseases, length of hospital stay, and number of medications received by the patients.
Drug-drug interactions were highly prevalent in the internal medicine ward. Therefore, certain attempts are required to increase the awareness of the physicians about these interactions and minimize their occurrence.
多种药物疗法常用于实现预期的治疗目标，尤其是在住院患者中。然而，药物相互作用可能会发生并威胁患者安全。
本研究旨在评估索巴教学医院内科病房潜在药物相互作用（PDDIs）的发生率和严重程度。
2021年6月至2021年12月在索巴教学医院内科病房进行了一项基于医院的回顾性横断面研究。数据从患者病历中收集。使用Lexicomp药物相互作用软件识别PDDIs。
本研究共纳入377例患者，PDDIs的总体发生率为62.9%。我们识别出989种潜在药物相互作用和345对相互作用药物，每位患者的PDDIs均值为4.17±4.079。在345种PDDIs中，大多数为中度相互作用，占70.1%（n=242），其次是轻度相互作用，占19.1%（n=66）。最常见的相互作用类型为C类，占63.5%（n=219）。观察到PDDIs的发生与患者年龄、慢性病的存在、住院时间以及患者接受的药物数量之间存在显著关联。
药物相互作用在内科病房非常普遍。因此，需要采取一定措施提高医生对这些相互作用的认识，并尽量减少其发生。
