Bundey S, Crawley J M, Edwards J H, Westhead R A
J Med Genet. 1979 Apr;16(2):117-21. doi: 10.1136/jmg.16.2.117.
In order to obtain control values for the diagnosis of carriers of Duchenne muscular dystrophy, creatine kinase (CK) estimations were performed in two laboratories on 148 healthy teenage girls (of whom 38 were premenarchal and 110 postmenarchal), 133 healthy mature women, 124 pregnant women, and 37 postmenopausal women. These levels were highest in the premenarchal teenagers, and became successively lower in the postmenarchal teenagers, the mature women, and the pregnant women, so that the mean level of the pregnant women was less than half that of the teenagers. The CK levels then rose again after the menopause. If the distribution of CK levels in adult non-pregnant women had been taken as controls for teenagers who were possible carriers for Duchenne muscular dystrophy, then one third of those teenagers classified as carriers would have been so classified incorrectly.
为了获得用于杜氏肌营养不良症携带者诊断的对照值，在两个实验室对148名健康少女（其中38名初潮前，110名初潮后）、133名健康成年女性、124名孕妇和37名绝经后女性进行了肌酸激酶（CK）测定。这些水平在初潮前青少年中最高，在初潮后青少年、成年女性和孕妇中依次降低，以至于孕妇的平均水平不到青少年的一半。绝经后CK水平又再次升高。如果将成年非孕妇的CK水平分布作为可能是杜氏肌营养不良症携带者的青少年的对照，那么三分之一被归类为携带者的青少年会被错误归类。
