Moss D W, Whitaker K B, Parmar C, Heckmatt J, Wikowski J, Sewry C, Dubowitz V
Clin Chim Acta. 1981 Oct 26;116(2):209-16. doi: 10.1016/0009-8981(81)90024-3.
Creatine kinase activity has been measured at 37 degrees C in sera from healthy women, carriers of Duchenne muscular dystrophy and cord blood, with activation by N-acetyl cysteine (NAC) and EDTA as recommended by several European committees on standardisation. The upper limit of the reference range for healty women was found to be 170 U/l. The distributions of creatine kinase activities in healthy and carrier women have been used to calculate probability of carrier status as a function of creatine kinase activity. Although the range of creatine kinase activities in normal cord blood is wide, the data provide a basis for interpretation when Duchenne muscular dystrophy is suspected.
按照欧洲几个标准化委员会的建议，在37摄氏度下测定了健康女性、杜兴氏肌营养不良症携带者以及脐血血清中的肌酸激酶活性，同时使用N-乙酰半胱氨酸（NAC）和乙二胺四乙酸（EDTA）进行激活。结果发现，健康女性的参考范围上限为170 U/l。已利用健康女性和携带者女性的肌酸激酶活性分布来计算作为肌酸激酶活性函数的携带者状态概率。尽管正常脐血中肌酸激酶活性范围较宽，但这些数据为怀疑患有杜兴氏肌营养不良症时的解读提供了依据。
