环八肽的构象。4. 环（甘氨酸-脯氨酸-苯丙氨酸-丙氨酸-天冬酰胺-丙氨酸-缬氨酸-丝氨酸）的非对映异构体
Conformations of cyclic octapeptides. 4. Diastereomers of cyclo(Gly-Pro-Phe-Ala-Asn-Ala-Val-Ser).
作者信息
Vishwanath C K, Go A, Parameswaran K N, Wang Y S, Kopple K D
出版信息
Int J Pept Protein Res. 1986 Oct;28(4):428-36.
PMID:3793373
Abstract
Stereoisomers of cyclo(Gly-Pro-Phe-Ala-Asn-Ala-Val-Ser) were synthesized. NMR studies of their solution conformations, focusing on peptide N-H solvent exposure, were made. These indicated that a single proline residue in the cyclic octapeptide ring is insufficient constraint to stabilize the backbone conformations that were previously established for cyclo(Gly-Pro-Phe-Ala)2.
摘要
合成了环（甘氨酸-脯氨酸-苯丙氨酸-丙氨酸-天冬酰胺-丙氨酸-缬氨酸-丝氨酸）的立体异构体。对其溶液构象进行了核磁共振研究，重点关注肽N-H与溶剂的接触情况。这些研究表明，环八肽环中的单个脯氨酸残基不足以稳定先前为环（甘氨酸-脯氨酸-苯丙氨酸-丙氨酸）₂所确立的主链构象。
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