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基于全球 ORF5 序列对 PRRSV-2 的遗传分类进行细化，并研究其地理分布和时间变化。

Refining PRRSV-2 genetic classification based on global ORF5 sequences and investigation of their geographic distributions and temporal changes.

机构信息

Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University , Ames, Iowa, USA.

Virus and Prion Research Unit, National Animal Disease Center, USDA-ARS , Ames, Iowa, USA.

出版信息

Microbiol Spectr. 2023 Dec 12;11(6):e0291623. doi: 10.1128/spectrum.02916-23. Epub 2023 Nov 7.

DOI:10.1128/spectrum.02916-23
PMID:37933982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10848785/
Abstract

In this study, comprehensive analysis of 82,237 global porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2) open reading frame 5 sequences spanning from 1989 to 2021 refined PRRSV-2 genetic classification system, which defines 11 lineages and 21 sublineages and provides flexibility for growth if additional lineages, sublineages, or more granular classifications are needed in the future. Geographic distribution and temporal changes of PRRSV-2 were investigated in detail. This is a thorough study describing the molecular epidemiology of global PRRSV-2. In addition, the reference sequences based on the refined genetic classification system are made available to the public for future epidemiological and diagnostic applications worldwide. The data from this study will facilitate global standardization and application of PRRSV-2 genetic classification.

摘要

在这项研究中，对 1989 年至 2021 年期间全球 82237 个猪繁殖与呼吸综合征病毒 2 型（PRRSV-2）开放阅读框 5 序列进行了全面分析，完善了 PRRSV-2 的遗传分类系统，该系统定义了 11 个谱系和 21 个亚谱系，如果未来需要增加谱系、亚谱系或更细粒度的分类，该系统具有灵活性。详细研究了 PRRSV-2 的地理分布和时间变化。这是对全球 PRRSV-2 分子流行病学的全面描述。此外，基于完善的遗传分类系统的参考序列也可供全球未来的流行病学和诊断应用使用。本研究的数据将促进 PRRSV-2 遗传分类的全球标准化和应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f72/10848785/5e3bfe77cda8/spectrum.02916-23.f010.jpg
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