Department of Neurology, Seventh Clinical College of China Medical University, 24 Central Street, Xinfu District, Fushun, Liaoning 113000, People's Republic of China.
Department of Neurology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning 110000, People's Republic of China.
J Agric Food Chem. 2023 Nov 22;71(46):17597-17614. doi: 10.1021/acs.jafc.3c06672. Epub 2023 Nov 7.
Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that occurs in old age and pre-aging, characterized by progressive cognitive dysfunction and behavioral impairment. Salidroside (Sal) is a phenylpropanoid mainly isolated from species with various pharmacological effects. However, the exact anti-AD mechanism of Sal has not been clearly elucidated. This meta-analysis aims to investigate the possible mechanisms by which Sal exerts its anti-AD effects by evaluating behavioral indicators and biochemical characteristics. A total of 20 studies were included, and the results showed that the Sal treatment significantly improved behavior abnormalities in AD animal models. With regard to neurobiochemical indicators, Sal treatment could effectively increase the antioxidant enzyme superoxide dismutase, decrease the oxidative stress indicator malondialdehyde, and decrease the inflammatory indicators interleukin 1β, interleukin 6, and tumor necrosis factor α. Sal treatment was effective in reducing neuropathological indicators, such as amyloid-β levels and the number of apoptotic cells. When the relevant literature on the treatment of rodent AD models is combined with Sal, the therapeutic potential of Sal through multiple mechanisms was confirmed. However, further confirmation by higher quality studies, larger sample sizes, and more comprehensive outcome evaluations in clinical trials is needed in the future.
阿尔茨海默病（AD）是一种中枢神经系统的神经退行性疾病，发生于老年前期和老年期，其特征为进行性认知功能障碍和行为损害。红景天苷（Sal）是一种苯丙素类化合物，主要从 物种中分离得到，具有多种药理作用。然而，Sal 确切的抗 AD 机制尚未明确。本荟萃分析旨在通过评估行为指标和生化特征，探讨 Sal 发挥抗 AD 作用的可能机制。共纳入 20 项研究，结果表明 Sal 治疗可显著改善 AD 动物模型的行为异常。在神经生化指标方面，Sal 治疗可有效增加抗氧化酶超氧化物歧化酶，降低氧化应激指标丙二醛，降低炎症指标白细胞介素 1β、白细胞介素 6 和肿瘤坏死因子 α。Sal 治疗还可降低神经病理学指标，如淀粉样蛋白-β水平和凋亡细胞数量。当将治疗啮齿动物 AD 模型的相关文献与 Sal 结合时，确认了 Sal 通过多种机制的治疗潜力。然而，未来仍需要更高质量的研究、更大的样本量以及临床试验中更全面的结局评估来进一步证实。
