Chen Guo, Zhang Ya, Zhou Yaqiao, Luo Hao, Guan Hongzhi, An Baiping
Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
J Inflamm Res. 2024 Dec 6;17:10421-10440. doi: 10.2147/JIR.S501270. eCollection 2024.
Despite advancements in cancer treatment through surgery and drugs, hepatocellular carcinoma (HCC) remains a significant challenge, as reflected by its low survival rates. The mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in regulating the cell cycle, proliferation, apoptosis, and metabolism. Notably, dysregulation leading to the activation of the mTOR signaling pathway is common in HCC, making it a key focus for in-depth research and a target for current therapeutic strategies. This review focuses on the role of the mTOR signaling pathway and its downstream effectors in regulating HCC cell proliferation, apoptosis, autophagy, cell cycle, and metabolic reprogramming. Moreover, it emphasizes the potential of natural products as modulators of the mTOR signaling pathway. When incorporated into combination therapies, these natural products have been demonstrated to augment therapeutic efficacy and surmount drug resistance. These products target key signaling pathways such as mTOR signaling pathways. Examples include 11-epi-sinulariolide acetate, matrine, and asparagus polysaccharide. Their inhibitory effects on these processes suggest valuable directions for the development of more effective HCC therapeutic strategies. Various natural products have demonstrated the ability to inhibit mTOR signaling pathway and suppress HCC progression. These phytochemicals, functioning as mTOR signaling pathway inhibitors, hold great promise as potential anti-HCC agents, especially in the context of overcoming chemoresistance and enhancing the outcomes of combination therapies.
尽管通过手术和药物在癌症治疗方面取得了进展，但肝细胞癌（HCC）仍然是一项重大挑战，其低生存率就反映了这一点。雷帕霉素靶蛋白（mTOR）信号通路在调节细胞周期、增殖、凋亡和代谢中起着关键作用。值得注意的是，导致mTOR信号通路激活的失调在HCC中很常见，这使其成为深入研究的重点和当前治疗策略的靶点。本综述重点关注mTOR信号通路及其下游效应器在调节HCC细胞增殖、凋亡、自噬、细胞周期和代谢重编程中的作用。此外，它强调了天然产物作为mTOR信号通路调节剂的潜力。当与联合疗法结合使用时，这些天然产物已被证明可以增强治疗效果并克服耐药性。这些产物靶向mTOR信号通路等关键信号通路。例子包括乙酸11-表-西努内酯、苦参碱和芦笋多糖。它们对这些过程的抑制作用为开发更有效的HCC治疗策略提供了有价值的方向。各种天然产物已证明能够抑制mTOR信号通路并抑制HCC进展。这些植物化学物质作为mTOR信号通路抑制剂，作为潜在的抗HCC药物具有很大的前景，特别是在克服化疗耐药性和提高联合疗法疗效方面。
