5β-双氢皮质醇对兔眼外植体中胶原蛋白合成的增强作用。
Potentiation of collagen synthesis in explants of the rabbit eye by 5 beta-dihydrocortisol.
作者信息
Southren A L, Hernandez M R, l'Hommedieu D, Gordon G G, Weinstein B I
出版信息
Invest Ophthalmol Vis Sci. 1986 Dec;27(12):1757-60.
The biologic effect of 5 beta-dihydrocortisol on collagen synthesis was evaluated. The metabolite was found to potentiate subthreshold levels of dexamethasone in increasing 3H-proline incorporation in cells of the outflow region of the rabbit. Digestion of the tissue with highly purified collagenase indicated that the 3H-proline was incorporated into collagen type protein. This study demonstrates another biologic activity of 5 beta-dihydrocortisol, a metabolite found to accumulate in cells cultured from trabeculectomy specimens from patients with primary open angle glaucoma.
评估了5β-二氢皮质醇对胶原蛋白合成的生物学效应。发现该代谢产物可增强地塞米松的阈下水平，从而增加兔眼流出区域细胞中3H-脯氨酸的掺入。用高度纯化的胶原酶消化组织表明，3H-脯氨酸掺入了胶原蛋白类型的蛋白质中。本研究证明了5β-二氢皮质醇的另一种生物学活性，该代谢产物在原发性开角型青光眼患者小梁切除标本培养的细胞中积累。
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