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巴基斯坦旁遮普省登革热疫情中的人口统计学和临床变量。

Demographic and clinical variables in the dengue epidemic in Punjab, Pakistan.

作者信息

Mushtaq Saira, Khan Malik Ihsan Ullah, Khan Muhammad Tahir, Husain Aamir

机构信息

Saira Mushtaq, M.Phil. Biochemistry Institute of Molecular Biology and Biotechnology, The University of Lahore KM Defence Road, Lahore, Pakistan.

Malik Ihsan Ullah Khan, Ph.D. Biology Institute of Molecular Biology and Biotechnology, The University of Lahore KM Defence Road, Lahore, Pakistan.

出版信息

Pak J Med Sci. 2023 Nov-Dec;39(6):1742-1746. doi: 10.12669/pjms.39.6.7383.

Abstract

OBJECTIVES

To identify the latest trends in the clinical picture and severity of the disease, which will help better understand and manage dengue.

METHODOLOGY

It was a cross-sectional, hospital-based study performed in the tertiary care hospitals of Punjab from August 21 to December 2022, in which serologically and polymerase chain reaction (PCR) confirmed patients with dengue infection, were enrolled. Demographic and clinical variables were recorded on a pre-tested Performa, processed and presented in frequency and percentages, and graphs were generated. Mean and standard deviation was used to present continuous variables.

RESULTS

Out of a total of 580 patients, 472 were diagnosed with Dengue Fever (DF) and 108 with Dengue Hemorrhagic Fever (DHF). About 79.31% of the patients were male and 20.69% were females. The mean age of patients was 32.5±9 years. Among the clinical features the percentage of high-grade fever, body aches, and vomiting were the highest. The liver function profile showed that serum bilirubin, Serum aspartate transaminase (AST), serum alanine transaminase (ALT,) and alkaline phosphatase (ALP) levels were markedly raised.

CONCLUSION

This study showed that with time the trends in the presentation of dengue are slowly shifting, which will help us better manage the disease burden in the future.

摘要

目的

确定该疾病临床表现和严重程度的最新趋势,这将有助于更好地理解和管理登革热。

方法

这是一项基于医院的横断面研究,于2022年8月21日至12月在旁遮普邦的三级护理医院进行,纳入了血清学和聚合酶链反应(PCR)确诊的登革热感染患者。在预先测试的表格上记录人口统计学和临床变量,进行处理并以频率和百分比呈现,并生成图表。使用均值和标准差来呈现连续变量。

结果

在总共580名患者中,472人被诊断为登革热(DF),108人被诊断为登革出血热(DHF)。约79.31%的患者为男性,20.69%为女性。患者的平均年龄为32.5±9岁。在临床特征中,高热、身体疼痛和呕吐的比例最高。肝功能检查显示血清胆红素、血清天冬氨酸转氨酶(AST)、血清丙氨酸转氨酶(ALT)和碱性磷酸酶(ALP)水平明显升高。

结论

本研究表明,随着时间的推移,登革热的表现趋势正在缓慢变化,这将有助于我们在未来更好地管理疾病负担。

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